AI Article Synopsis
- CDI (Clostridioides difficile infection) is a prevalent healthcare-associated infection, with symptoms that can range from mild diarrhea to severe pseudomembranous colitis.
- Toxins A (TcdA) and B (TcdB) are primarily responsible for the damaging effects on intestinal cells, leading to the symptoms of CDI, while around 20% of strains also produce a controversial binary toxin (CDT) that may enhance these effects.
- The text discusses the characteristics of CDT, its impact on human health, its relevance in clinical settings, its epidemiology, and potential treatments for CDI.
Article Abstract
Infection with (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are responsible for CDI symptomatology. Approximately 20% of strains produce a binary toxin (CDT) encoded by the and genes, which is thought to enhance TcdA and TcdB toxicity; however, the role of CDT in CDI remains controversial. Here, we focused on describing the main features of CDT and its impact on the host, clinical relevance, epidemiology, and potential therapeutic approaches.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146464 | PMC |
| http://dx.doi.org/10.3390/toxins14050305 | DOI Listing |
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