AI Article Synopsis
- The azole-directed cobalt-catalyzed asymmetric hydrogenation efficiently produces chiral pyrazole compounds with yields of nearly 100% and outstanding enantioselectivities (up to 99% ee) under mild conditions.
- The reaction can be scaled up to gram amounts, achieving a turnover number (TON) of up to 2000.
- This method shows practical applications, like adding β-chirality to drug intermediates with an azole ring.
Article Abstract
The azole-directed cobalt-catalyzed asymmetric hydrogenation of alkenes has been developed with high efficiency. With this approach, chiral pyrazole compounds were obtained in quantitative yields and excellent enantioselectivities (up to 99 % ee) under mild conditions, and the hydrogenation was conducted on a gram scale with up to 2000 TON. Several useful applications were demonstrated including the convenient introduction of β-chirality to a drug intermediate containing an azole ring.
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| http://dx.doi.org/10.1002/chem.202201517 | DOI Listing |
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