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Aseptic Meningitis and White Matter Disease in Childhood-Onset Neuropsychiatric Lupus.
Case Rep Rheumatol
December 2024
Department of Paediatrics, Queen Elizabeth Hospital, 30 Gascoigne Road, King's Park, Hong Kong.
We reported a 10-year-old girl who had an atypical demyelinating disease as the presentation of her neuropsychiatric lupus. The patient had a 4-year history of systemic lupus erythematosus which had been on remission until she presented with fever and headache at the age of 10 years. Physical examination showed meningism.
View Article and Find Full Text PDFBackground: Reduction in adult height by high-dose sex steroids was introduced decades ago. Here, we present the impact of lower doses of sex steroids on the predicted adult height in tall stature.
Methods: This single-center retrospective observational study included 22 tall children treated with low-dose sex steroids.
Risk factors of pediatric steroid-induced ocular hypertension.
Graefes Arch Clin Exp Ophthalmol
October 2024
Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Purpose: Steroid-induced ocular hypertension (SIOH) is a significant ocular complication of pediatric steroid administration. In this study, we analyzed the risk factors associated with pediatric SIOH.
Methods: We retrospectively collected data from 78 children under 20 years of age who received systemic steroids during hospitalization.
HIGH-DOSE INTRAVITREAL TOPOTECAN FOR RECURRENT RETINOBLASTOMA, SUBRETINAL SEEDS, AND VITREOUS SEEDS.
Retina
January 2025
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
Article Synopsis
- The study assessed the effectiveness and safety of high-dose intravitreal topotecan (IvitTopo) in treating patients with recurrent retinoblastoma, with outcomes focused on tumor control, eye preservation, and any potential treatment side effects.
- Thirteen patients, primarily infants, received high-dose IvitTopo after experiencing tumor recurrence, resulting in a significant regression of tumors in 92% of cases and complete eye salvage in all patients.
- The results suggest that high-dose IvitTopo is not only effective but also safe for managing recurrent retinoblastoma, and it may work well alone or alongside other treatments.
Development of a Preclinical Double Model of Mandibular Irradiated Bone and Osteoradionecrosis in New Zealand Rabbits.
Head Neck
October 2024
Guided Therapeutics (GTx) Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Purpose: Radiotherapy (RT) plays a crucial role in head and neck (HN) cancer treatment. Nevertheless, it can lead to serious and challenging adverse events such as osteoradionecrosis (ORN). A preclinical rabbit model of irradiated bone and ORN is herein proposed, with the aim to develop a viable model to be exploited for investigating new therapeutic approaches.
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