Excessive bleeding can complicate surgical intervention; this could be managed using an effective hemostatic agent that provides immediate and early bleeding control. Gelatin sponge and have been proven to have good hemostatic properties. The present study analyzed the cytotoxicity and hemostatic properties of gelatin sponge and . The cytotoxic concentration/effective concentration of was determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The drug release was determined using a vertical Franz diffusion cell apparatus; solid-state characterization was assessed using Fourier-transform infrared spectroscopy (FTIR) and a differential scanning calorimeter (DSC). The MTT assay showed 7% to be cytocompatible, and there was an increase in cell proliferation. When the 7% was loaded into the sponge, it was compatible, and the drug content was found to be 56.28 ± 13.84%. The time taken for the blood clot formation was measured using the Lee-White method. The gelatin sponge's time for clot formation was 161.70 ± 3.11 s, and the loaded gelatin sponge's time for clot formation was 158.75 ± 4.60 s. Hence, it could be concluded that when is incorporated into a gelatin sponge, it shows material compatibility and cytocompatibility, reduces the time for clot formation, and could be used as an alternative to other hemostatic agents.
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| http://dx.doi.org/10.3390/dj10050076 | DOI Listing |
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