AI Article Synopsis
- - The four-quadrant regimes of attainable polymorph crystallization (FQR-APC) was created using simulations to analyze the crystallization processes of a system with two different crystal forms.
- - A noteworthy observation was that a decrease in the most stable polymorphic form's composition in crystallized samples indicated the presence of concurrent polymorphism.
- - The study compared the FQR-APC with the Ostwald ratio (OR) and found that both methods effectively describe polymorphic outcomes, even though they stem from different theoretical backgrounds.
Article Abstract
The four-quadrant regimes of attainable polymorph crystallization (FQR-APC) plot was recently developed through numerical simulations of crystallization kinetics of a dipolymorphic system. Retraction in the polymorphic composition of the most stable form in crystallized samples was unveiled a characteristic indication of concomitant polymorphism. Comparisons were made with a recently developed concept, the Ostwald ratio (OR), in light of characterization of polymorphic formation. It was shown that both schemes display a good agreement in describing polymorphic outcomes, despite their distinct theoretical origins.
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| http://dx.doi.org/10.1021/acs.molpharmaceut.2c00125 | DOI Listing |
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