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Overexpression of miR-192 Inhibits In Vitro Porcine Embryo Development by Inducing Oxidative Stress Damage and Impairing Mitochondrial Function.
Animals (Basel)
December 2024
College of Animal Science and Technology, Shihezi University, Shihezi 832000, China.
Early embryonic development relies on intricately regulated gene expression, and miRNAs influence zygotic genome activation (ZGA), cleavage, and cell fate determination through post-transcriptional regulatory mechanisms. miR-192 is expressed in early pig embryos and participates in various reproductive processes. However, its role in pre-implantation pig embryo development remains poorly understood.
View Article and Find Full Text PDFRelationship between oxidative balance score and post-stroke depression: insights from the NHANES 2005-2018 cross-sectional study.
Front Neurol
November 2024
Department of Neurology, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi, China.
Introduction: The Oxidative Balance Score (OBS) represents an integrated measure of oxidative-reductive homeostasis. Despite the established role of oxidative stress in the development of post-stroke depression (PSD), the association between OBS and PSD in the general population remains unclear. This study aims to explore this relationship using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2018.
View Article and Find Full Text PDFRestoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation.
bioRxiv
January 2025
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
In multiple sclerosis (MS) the circulating metabolome is dysregulated, with indole lactate (ILA) being one of the most significantly reduced metabolites. We demonstrate that oral supplementation of ILA impacts key MS disease processes in two preclinical models. ILA reduces neuroinflammation by dampening immune cell activation as well as infiltration; and promotes remyelination and oligodendrocyte differentiation through the aryl hydrocarbon receptor (AhR).
View Article and Find Full Text PDFTrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1.
Redox Biol
September 2024
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, China. Electronic address:
Sepsis is a common complication of infections that significantly impacts the survival of critically patients. Currently, effective pharmacological treatment strategies are lacking. Auranofin, known as an inhibitor of Thioredoxin reductase (TrxR), exhibits anti-inflammatory activity, but its role in sepsis is not well understood.
View Article and Find Full Text PDFA comprehensive review of TGA transcription factors in plant growth, stress responses, and beyond.
Int J Biol Macromol
February 2024
School of Life Sciences, Chongqing University, Chongqing 401331, China; Chongqing Key Laboratory of Biology and Genetic Breeding for Tuber and Root Crops, Chongqing 400716, China. Electronic address:
TGA transcription factors (TFs), belonging to the D clade of the basic region leucine zipper (bZIP) family, exhibit a specific ability to recognize and bind to regulatory elements with TGACG as the core recognition sequence, enabling the regulation of target gene expression and participation in various biological regulatory processes. In plant growth and development, TGA TFs influence organ traits and phenotypes, including initial root length and flowering time. They also play a vital role in responding to abiotic stresses like salt, drought, and cadmium exposure.
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