AI Article Synopsis
- The study explores how fatigue affects multiple sclerosis (MS) patients by examining resting-state brain networks associated with fatigue.
- Researchers categorized 107 high-functioning MS patients into low-fatigue and high-fatigue groups and analyzed their neuroimaging data to see how different brain networks were connected.
- Results showed that fatigue correlates with differences in brain connectivity and activity, particularly in areas linked to awareness and perception of internal bodily states, suggesting higher fatigue levels are tied to these deficits.
Article Abstract
Background: Fatigue is one of the most common symptoms of multiple sclerosis (MS), significantly affecting the functioning of the patients. However, the neural underpinnings of physical and mental fatigue in MS are still vague. The aim of our study was to investigate the functional architecture of resting-state networks associated with fatigue in patients with MS.
Methods: The sum of 107 high-functioning patients underwent a resting-state scanning session and filled out the 9-item Fatigue Severity Scale (FSS). Based on the FSS score, we identified patients with different levels of fatigue using the cluster analysis. The low-fatigue group consisted of = 53 subjects, while the high-fatigue group = 48. The neuroimaging data were analyzed in terms of functional connectivity (FC) between various resting-state networks as well as amplitude of low-frequency fluctuation (ALFF) and fractional amplitude of low-frequency fluctuations (fALFF).
Results: Two-sample -test revealed between-group differences in FC of posterior salience network (SN). No differences occurred in default mode network (DMN) and sensorimotor network (SMN). Moreover, differences in fALFF were shown in the right middle frontal gyrus and right superior frontal gyrus, however, no ALFF differences took place.
Conclusion: Current study revealed significant functional network (FN) architecture between-group differences associated with fatigue. Present results suggest the higher level of fatigue is related to deficits in awareness as well as higher interoceptive awareness and nociception.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128356 | PMC |
| http://dx.doi.org/10.3389/fnhum.2022.852981 | DOI Listing |
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