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Correlation between liver volume drainage and clinical success after endoscopic biliary drainage of hilar malignant obstruction.

Clinics (Sao Paulo)

December 2024

Division of Endoscopy, Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brazil; Department of Gastroenterology of Universidade de São Paulo, São Paulo, SP, Brazil.

Background And Aim: Malignant hilar obstruction usually presents in advanced-stage disease with a poor prognosis. Effective biliary drainage is essential for the beginning of palliative chemotherapy. There is a debate on the amount of liver parenchyma that should be drained to achieve clinical success.

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Introduction The human lungs are located in the pleural cavity, divided by fissures into lobes, facilitating respiration movements. It acts as a barrier to prevent the spread of infection to adjacent lobes. The pulmonary hilum in each lung contains pulmonary vessels, bronchial vessels, and the bronchus.

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Article Synopsis
  • This study assesses the safety and effectiveness of unilateral versus bilateral radioactive stent (RS) insertion in patients with hilar cholangiocarcinoma (HCCA), involving 126 patients who underwent treatment from 2017 to 2021.
  • Results showed similar technical and clinical success rates, bilirubin levels, and complication rates between the two groups, but the unilateral group had a significantly higher rate of stent reinterventions.
  • Overall, the findings suggest that unilateral RS insertion is as effective as bilateral insertion for HCCA patients and may be favored due to its simplicity.
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Unilateral acute respiratory distress syndrome appearing contralateral to lung cancer.

Respir Med Case Rep

August 2024

Department of Respiratory Medicine, Kyoto Katsura Hospital, 17 Yamadahirao-cho, Nishikyo-ku, Kyoto, 615-8256, Japan.

Article Synopsis
  • * Despite urgent medical interventions, her condition worsened, and an autopsy revealed pleomorphic carcinoma in the right lung, with associated complications like stenosis of the right pulmonary artery and diffuse alveolar damage in the left lung.
  • * The findings highlight that unilateral Acute Respiratory Distress Syndrome (ARDS) is very rare but may occur in cases of lung cancer where there is compression of the pulmonary artery, leading to impaired lung function only on one side.
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Article Synopsis
  • - The study evaluated the effectiveness of inside stent therapy for patients with unresectable malignant hilar biliary obstruction, showing a high clinical success rate of 95.5% in resolving jaundice.
  • - Analysis identified factors influencing stent patency duration; unilateral drainage and chemotherapy were linked to significantly longer stent patency compared to bilateral drainage and no chemotherapy.
  • - The procedure was considered safe, with only a small percentage of patients experiencing early adverse events such as cholangitis and pancreatitis.
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