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| http://dx.doi.org/10.1016/j.amsu.2022.103751 | DOI Listing |
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Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Chem Pharm Bull (Tokyo)
January 2025
Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
Article Synopsis
- A-ring modifications in 1α,25-dihydroxyvitamin D enhance its binding to the vitamin D receptor (VDR) and increase its stability in cells by resisting metabolism, leading to longer-lasting effects.
- Various modified A-ring precursors synthesized from d-glucose showed specific biological activities with minimal calcemic side effects, including MART-10's potent antitumor effects in cancer models and AH-1's superior bone-forming properties in osteoporosis models compared to natural vitamin D.
- Ongoing research includes developing a library of fluorinated vitamin D analogs with potential anti-inflammatory effects and therapeutic applications for conditions like psoriasis, alongside the creation of the VDR-silent analog KK-052, which selectively inhibits SREBP/SC
Burning Tongue and Taste Alteration in Xerostomic Undiagnosed Diabetic Patients with Vitamin D Deficiency.
Diabetes Metab Syndr Obes
November 2024
Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University, Bandung, West Java, Indonesia.
Article Synopsis
- * A 44-year-old woman presented with these symptoms, and after blood tests and other assessments showed normal results, she was treated with several therapies including mouthwash and vitamins.
- * Further investigations revealed she had diabetes and vitamin D deficiency, leading to improved symptoms after targeted treatment, emphasizing the importance of thorough evaluations for similar cases.
Effect of Nicotinamide Riboside Against the Exhaustion of CD8 T Cells via Alleviating Mitochondrial Dysfunction.
Nutrients
October 2024
Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
: Targeting mitochondria and protecting the mitochondrial function of CD8 T cells are crucial for enhancing the clinical efficacy of cancer immunotherapy. : In this study, our objective was to investigate the potential of nicotinamide riboside (NR) in preserving the mitochondrial function of CD8 T cells and mitigating their exhaustion. : We established two in vitro models to induce CD8 T cell exhaustion either by tumor cell-conditioned medium (TCM) or by continuous stimulation with OVA peptide.
View Article and Find Full Text PDFAtherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Int J Angiol
December 2024
Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis. Ischemic stroke and heart disease, coronary heart disease, and cardiovascular disease are events resulting from long-lasting and silent atherosclerosis. This paper deals with the synthesis of homocysteine (Hcy), causes of HHcy, mechanism of HHcy-induced atherosclerosis, and treatment of HHcy.
View Article and Find Full Text PDFSIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells.
Int J Biol Sci
November 2024
Physiology Area, Department of Basic Health Sciences. Health Sciences Faculty, University Rey Juan Carlos, Alcorcón, Madrid, Spain.
Cancer initiation and progression result from genetic and epigenetic alterations caused by interactions between environmental and endogenous factors leading to aberrant cell signalling. Colorectal cancers (CRC) are linked to abnormal activation of the Wnt/β-catenin pathway, whose key feature is the nuclear accumulation of acetylated β-catenin in colon epithelial cells. Nuclear β-catenin acts as a transcriptional co-activator, targeting genes involved in cell proliferation and invasion.
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