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| http://dx.doi.org/10.3389/fimmu.2022.902945 | DOI Listing |
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Respiratory manifestations of sickle cell disease in children: a comprehensive review for the pediatrician.
Expert Rev Respir Med
January 2025
Department of Surgery, Dentistry, Pediatrics and Gynaecology, Pediatric Division, University of Verona, Verona, Italy.
Introduction: Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by the production of sickle hemoglobin, leading to red blood cells sickling and hemolysis in hypoxic conditions. The resulting acute and chronic endothelial inflammation leads to chronic organ damage. Respiratory manifestations in SCD usually start from childhood and represent the leading causes of morbidity and mortality.
View Article and Find Full Text PDFConnecting dots of long COVID-19 pathogenesis: a vagus nerve- hypothalamic-pituitary- adrenal-mitochondrial axis dysfunction.
Front Cell Infect Microbiol
December 2024
Clinical and Research Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Article Synopsis
- The pathogenesis of long COVID (LC) involves uncertainty, complicating the search for effective therapies.
- The hypothesis suggests that chronic damage to the body's anti-inflammatory mechanisms, particularly through the vagus nerve, HPA axis, and mitochondrial function, plays a crucial role in LC development.
- The theory posits that SARS-CoV-2 alters these systems at various levels, leading to persistent inflammation due to impaired anti-inflammatory responses from acetylcholine and cortisol, warranting further investigation into glucocorticoid receptor sensitivity and potential long-term epigenetic effects.
Skeletal muscle adaptations and post-exertional malaise in long COVID.
Trends Endocrinol Metab
December 2024
Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, The Netherlands; Amsterdam Movement Sciences Research Institute, Amsterdam, The Netherlands. Electronic address:
When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Symptoms experienced by patients often include myalgia, fatigue, brain fog, cognitive impairments, and post-exertional malaise (PEM), which is the worsening of symptoms following mental or physical exertion. There is little consensus on the pathophysiology of exercise-induced PEM and skeletal-muscle-related symptoms.
View Article and Find Full Text PDFEndothelial Dysfunction and Impaired Wound Healing Following Radiation Combined Skin Wound Injury.
Int J Mol Sci
November 2024
Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Article Synopsis
- There are currently no FDA-approved treatments for radiation combined injury (RCI) due to a limited understanding of its mechanisms.
- Research indicates that endothelial dysfunction contributes to higher mortality and delayed healing in RCI, as evidenced by increased body weight loss and skin wound complications in RCI mice compared to those with only skin wounds or radiation injury alone.
- The study also suggests that targeting endothelial dysfunction and the TGF-β signaling pathway could offer potential therapeutic strategies to improve healing and outcomes in patients with RCI.
Unlocking the potential of melanotransferrin (CD228): implications for targeted drug development and novel therapeutic avenues.
Expert Opin Ther Targets
December 2024
Research and Development Center, Shandong Boan Biotechnology Co., Ltd, Yantai, Shandong, China.
Introduction: Melanotransferrin (CD228), a cell membrane-anchored protein, has emerged as a significant cancer antigen due to its high expression in various solid tumors. This review synthesizes the current understanding and therapeutic potential of CD228.
Areas Covered: We conducted a literature search using PubMed, Web of Science, and ClinicalTrials.
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