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Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series. | LitMetric

Histologic evidence of tracheal stenosis directly resulting from SARS-CoV-2 tissue infiltration, a case series.

J Cardiothorac Surg

Division of Cardiothoracic Surgery, Department of Surgery, Mount Sinai South Nassau, Icahn School of Medicine at Mount Sinai, 1 Healthy Way, Oceanside, NY, 11572, USA.

Published: May 2022

Background: There has been an anecdotal increase in the incidence of tracheal stenosis that has coincided with the SARS-CoV-2 pandemic.

Case Presentation: This is a case series in which we report clinical and pathologic findings of two patients who subsequently developed subglottic tracheal stenosis after having been hospitalized with COVID-19 pneumonia. Histopathologic analysis of tissue from these patients shows features consistent with tissue infiltrated with SARS-CoV-2 virus, namely multinucleated syncytial cells with prominent nucleoli.

Conclusion: Our findings directly implicate SARS-CoV-2 in the pathogenesis of tracheal stenosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134720PMC
http://dx.doi.org/10.1186/s13019-022-01839-1DOI Listing

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