AI Article Synopsis
- The study aimed to evaluate whether administering betamethasone to mothers at 34-35 weeks of pregnancy speeds up the brain activity maturation in newborns, measured through amplitude integrated EEG (aEEG).
- Conducted as part of a larger trial, researchers collected aEEG data from 58 newborns (28 received betamethasone, 30 received a placebo) and compared various EEG maturation indicators at different time points.
- Findings revealed that while initial cycle frequencies were similar, betamethasone-exposed infants showed improved lower border voltage and greater span in their aEEG readings, indicating enhanced electrical activity in the brain. Further studies are needed to explore these changes in detail.
Article Abstract
Objective: Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation.
Study Design: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 34-35 weeks gestation before 72 h (aEEG 1) and at 5-7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity.
Results: 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage.
Conclusions: Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699898 | PMC |
| http://dx.doi.org/10.1038/s41372-022-01415-4 | DOI Listing |
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