AI Article Synopsis
- Mammalian innate lymphoid cells (ILCs) are essential for maintaining mucosal surface integrity and play significant roles in both normal and diseased conditions like inflammatory bowel disease (IBD).
- Key transcription factors like T-bet and RORγt are crucial for regulating different ILC subsets, impacting their development and function.
- The review discusses the balance between mature ILC1 and ILC3 and suggests that understanding the interactions between these transcription factors and other molecular pathways could lead to new therapeutic options for treating human diseases.
Article Abstract
Mammalian innate lymphoid cells (ILCs) have functional relevance under both homeostatic and disease settings, such as inflammatory bowel disease (IBD), particularly in the context of maintaining the integrity of mucosal surfaces. Early reports highlighted group 1 and 3 ILC regulatory transcription factors (TFs), T-box expressed in T cells (T-bet; Tbx21) and RAR-related orphan nuclear receptor γt (RORγt; Rorc), as key regulators of ILC biology. Since then, other canonical TFs have been shown to have a role in the development and function of ILC subsets. In this review, we focus on recent insights into the balance between mature ILC1 and ILC3 based on these TFs and how they interact with other key cell-intrinsic molecular pathways. We outline how this TF interplay might be explored to identify novel candidate therapeutic avenues for human diseases.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166716 | PMC |
| http://dx.doi.org/10.1016/j.it.2022.04.009 | DOI Listing |
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