An immunocompetent man in his 40s presented with 3 months of mid-thoracic back pain which progressed to include progressive paraesthesias and lower extremity weakness. Investigations revealed thoracic spine osteomyelitis with signs of cord compression. He underwent neurosurgical intervention, including laminectomy, spinal cord decompression and partial resection of an epidural mass. Initial intraoperative biopsy and surgical pathology results were concerning for an acid-fast bacillus as the causative pathogen, and the patient was given empiric therapy for presumed However, microbiology speciation revealed the presence of the non-tuberculous mycobacterium (NTM) , which resulted in an alteration of his antimicrobial therapy. This case highlights the importance of considering NTM as a possible aetiology of spinal osteomyelitis, even among immunocompetent individuals or in low-prevalence regions.
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http://dx.doi.org/10.1136/bcr-2022-249629 | DOI Listing |
Orthopadie (Heidelb)
December 2024
Orthopaedics and Traumatology Department, Kantonsspital Zug, Baar, Switzerland.
Introduction: We report the case of a 54-year-old male with the rare entity of bilateral septic acromioclavicular (AC) arthritis with osteomyelitis of the lateral clavicle with methicillin-susceptible Staphylococcus aureus (MSSA). The glenohumeral joint was affected as well. The patient was immunocompetent with no history of diabetes or intravenous drug abuse.
View Article and Find Full Text PDFBMC Infect Dis
December 2024
108 Military Central Hospital, Vietnamese - German Center for Medical Research (VG-CARE), N 1, Tran Hung Dao Str., Hai Ba Trung Dist, Hanoi, 1000, Vietnam.
Citrobacter youngae (C. youngae) was first described in 1993, and data suggesting that human diseases caused by this bacterium remain scarce. Reports on C.
View Article and Find Full Text PDFRadiol Case Rep
January 2025
Department of Infectious Disease, University of Illinois College of Medicine Peoria, 1 Illini Dr, Peoria IL 61605, USA.
Tuberculosis Spondylitis, also known as Pott's Disease, is an extrapulmonary form of tuberculosis (TB) that affects the spine. Sternal involvement is rare and accounts for only 0.3 % of cases.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
December 2024
Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150 Malaysia.
Skull base osteomyelitis (SBO) is a rare and lethal infection of temporal bone, uncommonly caused by purulent otitis media. Although uncommon, a young and immunocompetent person is not exceptional to develop SBO as in our case. We reported a case of SBO in a young, immunocompetent gentleman who presented with right otorrhea associated with fever, trismus, headache, and neck stiffness, which was unresponsive to oral and topical antibiotics.
View Article and Find Full Text PDFJ Pharm Pharmacol
November 2024
Division of Pharmacodynamics, Faculty of Pharmacy, Keio University, 1-5-30 Shiba koen, Minato-ku, Tokyo 105-8512, Japan.
Objectives: This study aimed to develop a suitable osteomyelitis model for pharmacokinetic/pharmacodynamic (PK/PD) evaluation and to investigate the target PK/PD values of vancomycin and tedizolid against methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis.
Methods: An osteomyelitis model was established by implanting an MRSA-exposed sterilized suture in the tibia of normal mice and mice with cyclophosphamide-induced neutropenia. The suitability of the osteomyelitis mouse model for PK/PD evaluation was assessed using vancomycin as an indicator.
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