Background: Cervical vestibular evoked myogenic potentials (cVEMPs) are surface-recorded responses that reflect saccular function. Analysis of cVEMPs has focused, nearly exclusively, on time-domain waveform measurements such as amplitude and latency of response peaks, but synchrony-based measures have not been previously reported.
New Method: Time-frequency analyses were used to apply an objective response-detection algorithm and to quantify response synchrony. These methods are new to VEMP literature and have been adapted from previous auditory research. Air-conducted cVEMPs were elicited using a 500 Hz tone burst in twenty young, healthy participants.
Results: Time-frequency characteristics of cVEMPs and time-frequency boundaries for response energy were established. An inter-trial coherence analysis approach revealed highly synchronous responses with representative inter-trial coherence values of approximately 0.7.
Comparison With Existing Methods: Inter-trial coherence measures were highly correlated with conventional amplitude measures in this group of young, healthy adults (R = 0.91 - 0.94), although the frequencies at which these measures had their largest magnitude were unrelated (R =.02). Conventional measures of peak-to-peak amplitude and latency were consistent with previous literature. Interaural asymmetry ratios were comparable between amplitude- and synchrony-based measures.
Conclusions: Synchrony-based time-frequency analyses were successfully applied to cVEMP data and this type of analysis may be helpful to differentiate synchrony from amplitude in populations with disrupted neural synchrony.
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http://dx.doi.org/10.1016/j.jneumeth.2022.109628 | DOI Listing |
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