AI Article Synopsis
- Cadmium (Cd) is an environmental pollutant that negatively impacts the adrenal glands of piglets, leading to tissue damage and apoptosis.
- Exposure to CdCl resulted in decreased antioxidant enzyme levels, increased heat shock proteins, and the activation of the PI3K/AKT pathway via miR-9-5p, which regulated apoptosis-related factors.
- The study utilized various methods including bioinformatics and assays to demonstrate that Cd exposure causes significant changes to gene expression and enzyme levels, providing insights into the toxicological effects of cadmium in animals.
Article Abstract
Cadmium (Cd) is an environmental pollutant that can cause endocrine organ damage. To explore the effect of subacute CdCl exposure on piglet adrenal gland tissue and its mechanism based on the establishment of this model, bioinformatics, TUNEL assay, western blot (WB), and qRT-PCR methods were used to detect related indicators. The results showed that after Cd exposure, antioxidant enzymes decreased, heat shock protein increased, and miR-9-5p-gene of phosphatase and tensin homolog (PTEN) upregulates the phosphatidylinositol-3-kinase (PI3K/AKT) pathway. After this pathway was activated, the expression of the apoptosis-related factors cysteinyl aspartate-specific proteinase 3 and 9 (caspase 3 and 9), B-cell lymphoma-2-associated X (BAX) was increased sharply, and the expression of B-cell lymphoma-2 (BCL2) was significantly decreased. The changes in these indicators indicate that Cd exposure induces apoptosis and causes tissue damage in the adrenal gland of piglets. This study aims to reveal the toxic effects of CdCl in animals and will provide new ideas for the toxicology of Cd.
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| http://dx.doi.org/10.1007/s11356-022-20734-9 | DOI Listing |
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