Self-Assembly of Polyurethane Phosphate Ester with Phospholipid-Like Structures: Spherical, Worm-Like Micelles, Vesicles, and Large Compound Vesicles.

Here, we report the preparation and self-assembly of amphiphilic polyurethane phosphate ester (PUP) polymers with phospholipid-like structures. The polymers, designed to have a hydrophilic phosphate head and two amphiphilic PPG-IPDI-MPEG (PU) tails were synthesized via coupling and phosphorylation reactions in sequence. These amphiphilic polymers could self-assemble into various interesting nanostructures in aqueous solution, such as spherical, worm-like micelles, vesicles, and large compound vesicles, depending on the hydrophobic chain length of PU tails and the initial polymer concentrations. It was found that the morphology transition is not only caused by the unique molecular structure of amphiphilic polyurethanes, but also influenced by the additional hydrophilic phosphate groups incorporated, which disturb the force balance governing the aggregation structures. This research supplies a new clue for the fabrication of well-defined nanostructures.