The N-methyladenosine modification (mA) modulates eukaryotic mRNA decay. In this issue of Cell Reports, Boo et al. describe a mechanism for degradation of mA-containing mRNAs by 5'-decapping, which occurs through the recruitment of the degradation factor UPF1 via the mA reader protein YTHDF2.
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| http://dx.doi.org/10.1016/j.celrep.2022.110898 | DOI Listing |
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