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| http://dx.doi.org/10.36660/abc.20210671 | DOI Listing |
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Out of Sight, Not Out of Mind: Vulval Fibroadenoma Revealed.
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Ectopic breast tissue (EBT) represents a congenital anomaly caused by incomplete regression of mammary ridges at the time of embryonic development. Typically, EBT presents along the mammary line, although usually in the axillary region, it has been located occasionally in unusual sites such as the vulva. Though relatively rare, it is generally subject to a wide range of pathologies that afflict normal breast tissue, encompassing both benign and malignant transformations.
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Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China.
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View Article and Find Full Text PDFBuilding Localized NADP(H) Recycling Circuits to Advance Enzyme Cascadetronics.
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University of Oxford, Chemistry, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
The catalytic action of enzymes of a cascade trapped within a mesoporous electrode material is simultaneously energized, controlled and observed through the efficient, reversible electrochemical NAD(P)(H) recycling catalyzed by one of the enzymes. In their nanoconfined state, nicotinamide cofactors are tightly channeled current carriers, mediating multi-step reactions in either direction (oxidation or reduction) with a rapid response time. By incorporating a hydrogen‑borrowing enzyme pair, the internal action of which opposes the external voltage bias driving oxidation or reduction, a reduction process can be performed under overall oxidizing conditions, and vice versa.
View Article and Find Full Text PDFUnusual Cutaneous Manifestations in a Patient with a History of Hepatitis B: A Case of Scleromyxedema and Literature Review.
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Scleromyxedema (SM) is a rare primary cutaneous mucinosis characterized by systemic papules and scleroderma-like manifestations, often associated with monoclonal gammopathy. We present the case of a 37-year-old male with SM who developed yellowish plaques on the neck and back over three years. Histopathological examination revealed mucin deposition, fibroblast proliferation, and fibrosis, supporting the diagnosis.
View Article and Find Full Text PDFExocrine pancreatic insufficiency as an unusual extrarenal manifestation of proximal renal tubular acidosis associated with a novel SLC4A4 mutation.
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Department of Pediatric Nephrology, Istanbul University- Cerrahpasa, Cerrahpasa Faculty of Medicine, 34098, Istanbul, Turkey.
Autosomal recessive proximal renal tubular acidosis (AR-pRTA) with ocular abnormalities is a rare syndrome caused by variants in the SLC4A4 gene, which encodes Na/HCO3 cotransporter (NBCe1). The syndrome primarily affects the kidneys, but also causes extra-renal manifestations. Pancreatic type NBCe1 is located at the basolateral membrane of the pancreatic ductal cells and together with CFTR chloride channel, it is involved in bicarbonate secretion.
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