[Secondary splenomegaly in cholestasis and disorders of portal blood flow in an experiment detectable by intravenous liposome splenography].

The paper is concerned with the results showing high diagnostic potentialities of i.v. liposome lienography for the detection of the splenomegalic syndrome in acute cholestasis, cholestatic hepatitis and disturbances of the extrahepatic portal blood flow. The authors managed to establish the dependence of the value of secondary splenomegaly on the period of cholestasis and a degree of occlusion of the portal vein. In acute cholestasis splenomegaly was manifested in 5 days by a two-fold increase in the spleen with reverse development within 2.5 mos. A rapid 2-fold increase in the spleen for 24 h was noted in occlusion of the portal vein by 40%, and a three-fold increase was noted in 5 mos. with subsequent death of the animals. A decrease in the extrahepatic portal blood flow by 25% also resulted in splenomegaly but without death of the animals. The authors have assumed that the use of i.v. liposome lienography ensures timely diagnosis of the splenomegalic syndrome and provides an opportunity to assess function of the reticuloendothelial system of the spleen.