AI Article Synopsis
- High-frequency (HF) rTMS may help reduce body weight in individuals with obesity, but its effects on patients with schizophrenia (SZ) had not been studied prior to this research.
- The study involved 47 SZ patients who received either 10Hz rTMS or sham stimulation daily for four weeks, with body weight and clinical symptoms measured at multiple points.
- Results showed that the 10Hz rTMS group lost significantly more weight over the four weeks than the sham group, though there was no improvement in psychotic symptoms with the active treatment.
Article Abstract
Objectives: There is emerging evidence that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) may promote weight loss in individuals with obesity in the general population. However, no study has been conducted on patients with schizophrenia (SZ). This study evaluated the efficacy of 10Hz rTMS in reducing body weight in patients with chronic SZ.
Methods: Forty-seven SZ patients were randomly assigned to two groups: 10Hz rTMS or sham stimulation over DLPFC (applied once daily) for 20 consecutive treatments. Body weight was assessed at baseline, at the end of week 1, week 2, week 3 and week 4. Clinical symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) at baseline and at the end of week 4.
Results: We found that compared with patients in the sham group, 10Hz rTMS treatment significantly reduced body weight in patients with chronic SZ after a period of 4 weeks of stimulation. Interestingly, further analysis found that from the first week (5 sessions) of treatment, there was a significant difference in body weight between active and sham groups after controlling for baseline weight. However, active rTMS treatment did not improve the psychotic symptoms compared to sham stimulation.
Conclusion: Our results suggest that add-on HF rTMS could be an effective therapeutic strategy for body weight control in patients with chronic SZ.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10190142 | PMC |
| http://dx.doi.org/10.2174/1570159X20666220524123315 | DOI Listing |
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