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Extracellular Vesicle Mobility in Collagen I Hydrogels Is Influenced by Matrix-Binding Integrins.
ACS Nano
October 2024
Max Planck Institute of Colloids and Interfaces, Science Park Golm, Potsdam 14476, Germany.
Article Synopsis
- * Current research investigates how EVs navigate different tissue environments and their interactions with components of the extracellular matrix, which influence their movement and distribution.
- * Using advanced microscopy techniques, the study finds that proteins on the EV surface are crucial for their attachment to collagen I hydrogels, and inhibiting certain integrins can enhance EV mobility, potentially improving cancer treatment strategies.
Free-swimming bacteria transcriptionally respond to shear flow.
Proc Natl Acad Sci U S A
October 2024
Department of Molecular Biology, Princeton University, Princeton, NJ 08544.
Surface-attached cells can sense and respond to shear flow, but planktonic (free-swimming) cells are typically assumed to be oblivious to any flow that carries them. Here, we find that planktonic bacteria can transcriptionally respond to flow, inducing expression changes that are beneficial in flow. Specifically, we use microfluidic experiments and quantitative modeling to show that in the presence of flow, planktonic induce shear rate-dependent genes that promote growth in low-oxygen environments.
View Article and Find Full Text PDFVariations of organic functional chemistry in carbonaceous matter from the asteroid 162173 Ryugu.
Nat Commun
August 2024
Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Sagamihara, Japan.
Primordial carbon delivered to the early earth by asteroids and meteorites provided a diverse source of extraterrestrial organics from pre-existing simple organic compounds, complex solar-irradiated macromolecules, and macromolecules from extended hydrothermal processing. Surface regolith collected by the Hayabusa2 spacecraft from the carbon-rich asteroid 162173 Ryugu present a unique opportunity to untangle the sources and processing history of carbonaceous matter. Here we show carbonaceous grains in Ryugu can be classified into three main populations defined by spectral shape: Highly aromatic (HA), Alkyl-Aromatic (AA), and IOM-like (IL).
View Article and Find Full Text PDFUnveiling the evolution of policies for enhancing protein structure predictions: A comprehensive analysis.
Comput Biol Med
September 2024
Department of Computer Engineering, Technical and Vocational University (TVU), Tehran, Iran.
Predicting protein structure is both fascinating and formidable, playing a crucial role in structure-based drug discovery and unraveling diseases with elusive origins. The Critical Assessment of Protein Structure Prediction (CASP) serves as a biannual battleground where global scientists converge to untangle the intricate relationships within amino acid chains. Two primary methods, Template-Based Modeling (TBM) and Template-Free (TF) strategies, dominate protein structure prediction.
View Article and Find Full Text PDFUntangling the Molecular Interactions Underlying Intracellular Phase Separation Using Combined Global Sensitivity Analyses.
Bull Math Biol
April 2024
Department of Mathematics, Florida State University, Tallahassee, FL, USA.
Liquid-liquid phase separation is an intracellular mechanism by which molecules, usually proteins and RNAs, interact and then rapidly demix from the surrounding matrix to form membrane-less compartments necessary for cellular function. Occurring in both the cytoplasm and the nucleus, properties of the resulting droplets depend on a variety of characteristics specific to the molecules involved, such as valency, density, and diffusion within the crowded environment. Capturing these complexities in a biologically relevant model is difficult.
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