The Dissemination of Fusidic Acid Resistance Among Clinical Isolates in Wenzhou, China.

Infect Drug Resist

Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China.

Published: May 2022

Purpose: Fusidic acid (FA), a potent steroidal antibiotic, is used topically to treat skin and soft tissue infections (SSTIs) caused by . The aim of this study is to report the prevalence of fusidic acid resistance among clinical isolates from a tertiary hospital in Wenzhou, east China.

Methods: The antibiotic susceptibility of isolates was determined by disc diffusion method and agar dilution method. Then, FA-resistant isolates were characterized by multi-locus sequence typing, SCC typing and pulsed-field gel electrophoresis.

Results: In the present study, the 55 (7.7%) FA-resistant among 711 clinical isolates were isolated from different parts of 53 patients. Fifty-five FA-resistant isolates with FA MIC values ranged from 4 to 32 μg/mL. Among them, 50 (90.9%) were identified as methicillin-resistant (MRSE), in which were positive. Meanwhile, the positive rates of and genes among FA-resistant isolates were 85.5% (47/55) and 7.3% (4/55), respectively. All 55 isolates mentioned above were susceptible to vancomycin. More than 50% of FA-resistant isolates were resistant to non-β-lactam antimicrobials including erythromycin (80.0%, 44/55), clindamycin (65.5%, 36/55), ciprofloxacin (63.6%, 35/55) and sulfamethoxazole (63.6%, 35/55). A total of 14 sequence types (STs) were identified among the 55 FA-resistant isolates, of which, ST2 (24/55, 43.6%) was the most predominant type. And the eBURST analysis showed that CC2, CC5 and CC247 accounted for 43.6% (24/55), 27.3% (15/55) and 14.5% (5/55), respectively. Meanwhile, a total of four SCC types (I, III, IV, V) were identified among the 55 FA-resistant . Furthermore, the pulsed field gel electrophoresis divided the 55 isolates into 20 types, namely A-T. Q-type strains were most prevalent, accounting for 30.9% (17/55).

Conclusion: Taken together, the dissemination of ST2 clone with FA resistance can cause trouble in controlling infections.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123912PMC
http://dx.doi.org/10.2147/IDR.S365071DOI Listing

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