Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging.

Background: The pursuit of health and longevity is the eternal theme of humanity. Guangxi has a remarkable phenomenon of longevity in long-lived regions and ranks with the highest number of longevity villages in China, thus providing a natural advantage for health longevity research.

Methods: In this study, we selected 117 natives of a longevity area in Guangxi, covering a large age range (38-118 years old) as subjects to measure peripheral leukocyte telomere length (LTL). Nineteen physical examination indicators and two inflammatory factor levels were measured.

Results: Pearson's analysis revealed a significant negative correlation between age and LTL ( = -0.3694, = 0.003), as well as alanine aminotransferase, albumin, total bilirubin, direct bilirubin, -glutamyltransferase, triglycerides, Interleukin-10, and tumor necrosis factor type-. Systolic blood pressure and blood urea nitrogen were positively correlated with age. In addition, LTL decreased in people aged 38-89 years, and an upward trend was observed in people aged older than 90 years.

Conclusions: Longevity individuals have characteristics, such as longer LTL, good hepatic function, and lower triglycerides and inflammation levels.