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Characterisation and evaluation of physical properties of AH-Plus sealer with and without the incorporation of petasin, pachymic acid, curcumin and shilajit-an invitro study.
BMC Oral Health
March 2024
Department of Conservative Dentistry and Endodontics, SRM Dental College, Bharathi Salai, Chennai, Tamil Nadu, 600089, India.
Background: AH Plus, an epoxy resin-based sealer, is widely used in endodontic practice, owing to its good physical properties that confers longstanding dimensional stability and good adhesion to dentin. Nevertheless, its propensity to trigger inflammation, especially in its freshly mixed state, has been extensively documented. Phytochemicals such as Petasin, Pachymic acid, Curcumin, and Shilajit are known for their anti-inflammatory and analgesic effects.
View Article and Find Full Text PDFGreen synthesis of zinc oxide nanoparticles using aqueous extract of shilajit and their anticancer activity against HeLa cells.
Sci Rep
January 2024
Department of Molecular and Cell Biology Lab, Greensmed Labs, Thoraipakkam, Chennai, 600097, India.
In the present study, ZnO nanoparticles have been synthesized using an aqueous extract of shilajit. The nanoparticles were characterized using different techniques such as UV (ultraviolet-visible spectrophotometer), FTIR (Fourier transform infrared), XRD (X-ray diffraction), particle size analysis, SEM (scanning electron microscope) and EDAX (Energy-dispersive X-ray) analysis. The UV absorption peak at 422.
View Article and Find Full Text PDFHistopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury.
Ulus Travma Acil Cerrahi Derg
December 2023
Department of Neurosurgery, Faculty of Medicine, Van Yüzüncü Yıl University, Van-Türkiye.
Background: This experimental study was designed to investigate the histopathological and immunohistochemical effects of Shilajit in rats with experimentally induced spinal cord injury (SCI).
Methods: The rats were divided into three groups: Control group: The group in which spinal cord damage was created but no drug was administered. Low-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 150 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced.
Effects of 8 Weeks of Shilajit Supplementation on Serum Pro-c1α1, a Biomarker of Type 1 Collagen Synthesis: A Randomized Control Trial.
J Diet Suppl
December 2023
Department of Nutrition and Health Sciences, University of Nebraska- Lincoln, Lincoln, NE, USA.
Type 1 collagen is an abundant structural protein with importance to the skin, eyes, bones, ligaments, tendons, and muscles. Shilajit supplementation has been shown to increase gene expression of collagen synthesis, however, it is unclear if increased gene expression translates to increases in circulating levels. Therefore, the purpose of the present study was to examine the effects of 8 weeks of daily supplementation with 500 mg·d and 1000 mg·d of Shilajit versus placebo on serum pro-c1α1, a biomarker of type 1 collagen synthesis.
View Article and Find Full Text PDFAccelerating effect of Shilajit on osteogenic property of adipose-derived mesenchymal stem cells (ASCs).
J Orthop Surg Res
September 2022
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Article Synopsis
- Shilajit has been traditionally used in Iranian folk medicine to treat various ailments, including bone defects, and this study investigates its effect on osteogenic differentiation of human adipose-derived mesenchymal stem cells (ASCs) in both 2D and 3D cultures.
- In 3D culture experiments using alginate hydrogel with Shilajit, results showed enhanced alkaline phosphatase activity and increased calcium deposition, indicating that Shilajit promotes osteogenic differentiation more effectively than in 2D cultures.
- The findings suggest that Shilajit, when combined with alginate hydrogel, can accelerate the differentiation of ASCs into bone-forming cells without altering the physical properties of the hydrogel, highlighting its potential
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