Intravesical Bacillus Calmette-Guérin (BCG) administration was used to treat bladder carcinoma in a woman in her 60s. Severe bilateral non-granulomatous anterior uveitis and gross papillitis developed subsequently. The severe BCG-induced bilateral uveitis and papillitis were treated with high dose oral corticosteroids, with topical steroids and cycloplegics. Resolution of her ocular symptoms and signs eventuated. On lumbar puncture, no evidence of systemic spread of the BCG was found. Visual acuity returned to 6/9 in each eye with subsequent resolution of papillitis. Repeat cystoscopy demonstrated no evidence of recurrent bladder tumour.Hypersensitivity reactions are well recognised with While both hypersensitivity reactions and dissemination of BCG throughout the body have been previously documented, the literature demonstrates that this case is the first example in which papillitis and bilateral uveitis were the prominent ophthalmological features.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174766PMC
http://dx.doi.org/10.1136/bcr-2021-247578DOI Listing

Publication Analysis

Top Keywords

bacillus calmette-guérin
8
bilateral uveitis
8
papillitis
5
papillitis uveitis
4
uveitis complicating
4
complicating bacillus
4
calmette-guérin immunotherapy
4
immunotherapy intravesical
4
intravesical bacillus
4
calmette-guérin bcg
4

Similar Publications

Detection and characterization of pathogenic Bacillus haynesii from Tribulus terrestris extract: ways to reduce its levels.

Braz J Microbiol

January 2025

Innovation and Drug Discovery, Sava Healthcare Limited, Research Center, MIDC, Block D1, Plot No. 17/6, Chinchwad, Pune, 411019, India.

Plant parts such as roots, bark, leaves, flowers, and fruits that hold ethnopharmacological significance are naturally prone to microbial contamination, influenced by environmental factors like moisture and humidity. This study focuses on assessing the microbial load in the raw material of Tribulus terrestris (TT). The primary bacterium isolated from the pulverized raw material was identified as Bacillus haynesii through 16S rRNA sequencing.

View Article and Find Full Text PDF

Biofilm formation by the plant growth promoting bacterium Bacillus cereus (EB-40).

Braz J Microbiol

January 2025

Programa de Pós-Graduação em Produção Vegetal no Semiárido, Universidade Estadual de Montes Claros, Rua Reinaldo Viana, 2650, Janaúba, MG, 39400-000, Brazil.

The objective of this work was to investigate the biofilm production capacity of the isolate EB-40 (Bacillus cereus) in a culture medium for the multiplication of microorganisms and in roots of in vitro grown banana explants. It was observed that the isolate was able to produce biofilms in tryptone, soy and agar (TSA) culture medium and in the roots of explants. The format, architecture and location of the biofilms in TSA culture medium presented an exopolymer matrix formed by EB-40 presented coccoid bacillary cells and fibrillar structures.

View Article and Find Full Text PDF

is one of the commonly used hosts for heterologous enzyme expression, depending on media rich in carbon, nitrogen, and phosphate sources for optimal growth and enzyme production. Interestingly, our investigation of maltotetraose-forming amylase, a key enzyme for efficient maltotetraose synthesis, revealed that phosphate limitation significantly enhances the growth rate and production of heterologous enzymes in recombinant . Under phosphate-limited conditions in a 15 L fermenter, the enzyme activity reached 679.

View Article and Find Full Text PDF

The 55-carbon isoprenoid, undecaprenyl-phosphate (UndP), is a universal carrier lipid that ferries most glycans and glycopolymers across the cytoplasmic membrane in bacteria. In addition to peptidoglycan precursors, UndP transports O-antigen, capsule, wall teichoic acids, and sugar modifications. How this shared but limited lipid is distributed among competing pathways is just beginning to be elucidated.

View Article and Find Full Text PDF

The Cry1Fa insecticidal protein from (Bt) was expressed on the surface of (Bs) spores to create transgenic Bs spores referred to as Spore-Cry1Fa. Cry1Fa, along with its leader sequence, was connected to the carboxyl end of a Bs spore outercoat protein, CotC, through a flexible linker. The Arg-27 residue of the Cry1Fa protein was mutated to Leu to prevent detachment from the spores due to protease digestion.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!