AI Article Synopsis
- Warm autoimmune hemolytic anemia is a rare condition that can occur on its own or due to other diseases, including chronic issues like primary sclerosing cholangitis.
- A case study is presented involving a woman in her 50s who developed this anemia during an infection without prior signs of hemolysis.
- She was treated effectively with antibiotics and careful blood transfusions while avoiding immunosuppressive therapy due to her sepsis, illustrating the importance of a customized treatment plan for such complex cases.
Article Abstract
Warm autoimmune haemolytic anaemia mediated by warm agglutinins is a rare and heterogeneous disease which can be idiopathic or secondary to an underlying disease. Primary sclerosing cholangitis is a chronic autoimmune cholangiopathy that is very rarely associated with haemolytic anaemia. Infections can also act as triggers for immune haemolytic anaemia. Here, we report a case of a woman in her 50s with a history of primary sclerosing cholangitis and a positive direct antiglobulin test with no evidence of haemolysis who developed overt warm autoimmune haemolytic anaemia in the setting of cholangitis and bacteraemia. She was treated conservatively with appropriate antibiotics and cautious red blood cell transfusion with complete resolution of haemolysis; immunosuppression was avoided given sepsis on presentation. This case highlights a rare association of warm immune haemolytic anaemia in the setting of bacteraemia and the role of a tailored treatment approach to treat this heterogeneous disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174818 | PMC |
| http://dx.doi.org/10.1136/bcr-2021-248339 | DOI Listing |
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