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Postintubation Tracheal Rupture in a Patient With Herpes Simplex Virus Type 1 (HSV-1) Tracheitis.
Cureus
October 2024
Pulmonary and Critical Care, University of Oklahoma Health Sciences Center, Oklahoma, USA.
Article Synopsis
- * A 70-year-old woman with diabetes presented with altered mental status due to diabetic ketoacidosis and pneumonia, was intubated for airway protection, but developed complications after extubation that led to cardiopulmonary arrest.
- * After resuscitation and further evaluation, her stridor was linked to tracheal injury caused by HSV-1, confirmed through bronchoscopy and biopsy, leading to successful antiviral treatment and eventual recovery following
Getting the dose right using physiologically-based pharmacokinetic modeling: dexamethasone to prevent post-extubation stridor in children as proof of concept.
Front Pediatr
July 2024
Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands.
Introduction: Critically ill patients show large variability in drug disposition due to e.g., age, size, disease and treatment modalities.
View Article and Find Full Text PDFAir leak test in the Paediatric Intensive Care Unit (ALTIPICU): rationale and protocol for a prospective multicentre observational study.
BMJ Open
April 2024
Médecine Intensive-Réanimation Pédiatrique, Robert-Debré Mother-Child University Hospital, Paris, Île-de-France, France.
Introduction: In children, respiratory distress due to upper airway obstruction (UAO) is a common complication of extubation. The quantitative cuff-leak test (qtCLT) is a simple, rapid and non-invasive test that has not been extensively studied in children. The objective of the ongoing study whose protocol is reported here is to investigate how well the qtCLT predicts UAO-related postextubation respiratory distress in paediatric intensive care unit (PICU) patients.
View Article and Find Full Text PDFPosition paper of diagnosis and treatment of post-extubation laryngitis in children: a multidisciplinary expert-based opinion.
Braz J Otorhinolaryngol
May 2024
Universidade Estadual de Campinas (UNICAMP), Hospital de Clínicas, Campinas, SP, Brazil.
Objectives: To make recommendations on the diagnosis and treatment of post-extubation laryngitis (PEL) in children with or without other comorbidities.
Methods: A three-iterative modified Delphi method was applied. Specialists were recruited representing pediatric otolaryngologists, pediatric and neonatal intensivists.
Factors associated with laryngeal injury after intubation in children: a systematic review.
Eur Arch Otorhinolaryngol
June 2024
Department of Otorhinolaryngology, Erasmus Medical Center, Sophia Children's Hospital, Room SP 1421a, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands.
Article Synopsis
- The study aims to evaluate factors linked to laryngeal injury following endotracheal intubation in children through a systematic review of existing literature.
- A total of 24 relevant articles covering 15,520 patients were analyzed, revealing varying incidences of post-extubation complications; confirmed factors like sedation level and gastro-esophageal reflux were identified, while other factors such as age and intubation duration had unclear associations.
- The findings highlight the limited quality of evidence on the discussed factors, aiming to clarify their roles in laryngeal injury risk in pediatric patients post-intubation.
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