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Repurposing Historic Drugs for Neutrophil-Mediated Inflammation in Skin Disorders.
Biomolecules
November 2024
Dermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padova, Italy.
Neutrophil-mediated inflammation is a key feature of immune-mediated chronic skin disorders, but the mechanistic understanding of neutrophil involvement in these conditions remains incomplete. Dapsone, colchicine, and tetracyclines are established drugs within the dermatologist's therapeutic armamentarium that are credited with potent anti-neutrophilic effects. Anti-neutrophilic drugs have established themselves as versatile agents in the treatment of a wide range of dermatological conditions.
View Article and Find Full Text PDFEcthyma Gangrenosum Caused by Klebsiella Pneumoniae: A Rare Entity with Devastating Consequences.
Rev Med Chil
July 2024
Resident Department of Dermatology, Faculty of Medicine, University of Chile, Santiago, Chile.
This report describes the case of a 64-year-old female patient, with multiple comorbidities which presented an ecthyma gangrenosum due to Klebsiella pneumoniae confirmed by blood and tissue cultures. It finally ended in the amputation of the limb. The case is presented given the low prevalence of positive cultures for this microorganism in this pathology associated to devastating consequences for the patient.
View Article and Find Full Text PDFA case of treatment-resistant erosive pustular dermatosis of the scalp.
SAGE Open Med Case Rep
January 2025
Memorial University of Newfoundland, St. John's, NL, Canada.
Erosive pustular dermatosis is a rare and chronic inflammatory condition of the scalp which can be mistaken for cutaneous malignancy, precancerous lesions, dermatitis or pyoderma gangrenosum. The recurrent and resistant characteristics of erosive pustular dermatosis of the scalp pose a challenge to successful management and remission of the condition. The purpose of this case report is to provide management options and treatment recommendations for refractory cases of erosive pustular dermatosis of the scalp.
View Article and Find Full Text PDFPyoderma Gangrenosum: A Nightmare for Breast Surgery-Two Case Reports.
Eur J Breast Health
January 2025
Department of General Surgery, Gülhane Training and Research Hospital, University of Health Sciences Turkey, Ankara, Turkey.
Article Synopsis
- Pyoderma gangrenosum (PG) is a rare skin condition that causes painful ulcers and is often incorrectly diagnosed as an infection.
- The report discusses two cases of PG following breast surgeries, where both patients initially received ineffective treatment through debridements and antibiotics.
- Effective treatment was achieved using oral doxycycline and topical tacrolimus, highlighting the importance of early diagnosis and proper management to prevent patient suffering and disfigurement.
Bullous Pyoderma Gangrenosum Associated with Antiphospholipid Syndrome: A Case Report and Literature Review.
Oman Med J
July 2024
Family Medicine General Foundation Program, Oman Medical Specialty Board, Muscat, Oman.
We report a rare case of a middle-aged Omani woman who was known to have primary antiphospholipid syndrome, glucose-6-phosphate dehydrogenase deficiency, and iron deficiency anaemia. Cannulation attempts caused bulla which progressed to ulceration. A pathergy phenomenon with high suspicion of pyoderma gangrenosum was postulated.
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