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Internalizing Psychiatric Symptoms in People With Mosaicism for Trisomy 21.
Am J Med Genet B Neuropsychiatr Genet
January 2025
Department of Pathology, Virginia Commonwealth University, Richmond, Virginia, USA.
People with mosaicism for trisomy 21 have been shown to exhibit many of the same phenotypic traits present in people with non-mosaic Down syndrome, but with varying symptom severity. However, the behavioral phenotype of people with mosaic Down syndrome (mDS) has not been well characterized. This study aimed to examine the prevalence of self-report and caregiver-report symptoms of depression and anxiety among a sample of 62 participants with mDS aged 12-46 and assess their association with the percentage of trisomy 21 in blood and/or buccal mucosa cells.
View Article and Find Full Text PDFComparative Evaluation of Microleakage in Class V Cavities Restored with Newer Bioactive Restorative Materials: Activa Bioactive Restorative and Activa Pronto.
Int J Clin Pediatr Dent
November 2024
Private Practitioner, Bengaluru, Karnataka, India.
Aim: To compare the microleakage in class V cavities restored with Activa Bioactive Restorative, Activa Pronto, and nanohybrid composite.
Materials And Methods: Standardized class V cavity preparations (mesiodistal: 3 mm; occlusocervical: 2 mm; axial depth: 1 mm) were made on the buccal surface of 60 extracted intact maxillary premolar teeth. The preparations were divided into three experimental groups ( = 20) depending on the restorative material used.
Giant odontoma: A systematic scoping review and case report.
Int J Surg Case Rep
January 2025
Department of Oral and Maxillofacial Surgery, School of Dentistry, Azad University of Medical Sciences, Shiraz, Iran.
Introduction And Importance: The most common type of odontogenic tumor is odontoma. Cases with at least one dimension (sagittal, axial, or coronal) ≥30 mm were categorized as giant odontomas. This study aimed to provide a scoping review of giant odontoma and present a case report.
View Article and Find Full Text PDFPedicle ossification following mandibular reconstruction using fibular free flap in a patient with osteoradionecrosis of the jaw: a case report.
J Korean Assoc Oral Maxillofac Surg
December 2024
Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Article Synopsis
- Pedicle ossification is a rare complication that can occur after using a fibular free flap (FFF) for mandibular reconstruction, potentially simulating tumor recurrence and leading to diagnostic challenges.
- A case study of a 38-year-old male with squamous cell carcinoma highlighted how postoperative complications led to the need for FFF reconstruction, and over 4 years, CT scans showed ossification in the flap's vascular pedicle, yet the patient remained asymptomatic.
- Regular imaging and clinical assessments are key to distinguishing ossification from tumor recurrence, with surgery usually only considered if symptoms arise.
The effect of commonly employed forensic DNA extraction protocols on ssDNA/dsDNA proportion and DNA integrity.
Forensic Sci Int Genet
December 2024
Estonian Forensic Science Institute, Tallinn, Estonia.
The utilisation of massively parallel sequencing (MPS) in forensic DNA analysis is on the rise, driven by the expansion of targeted MPS panels in the market and the introduction of forensic investigative genetic genealogy. The MPS library preparation process, integral to both whole-genome sequencing (WGS) and targeted MPS panel data generation, is largely based on converting double-stranded DNA (dsDNA) into sequencing libraries. In the current study, we examined the effect of seven routinely used forensic DNA extraction methods on the strandedness (single-stranded or double-stranded) and the fragment size of the DNA extracted from buccal swab, blood, bone and tooth samples.
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