AI Article Synopsis
- Myelofibrosis is a blood cancer causing symptoms like enlarged spleen, severe fatigue, and bone marrow failure, often leading to anemia that negatively impacts life quality and survival.
- Momelotinib is a drug that inhibits certain proteins (JAK1/JAK2) and decreases a hormone (hepcidin) to boost iron availability for red blood cell production, showing promise in clinical tests.
- The review discusses the background, clinical trial results, and potential future uses of momelotinib as a treatment for myelofibrosis patients with anemia.
Article Abstract
Myelofibrosis is a myeloproliferative neoplasm characterized by splenomegaly, debilitating constitutional symptoms and bone marrow failure. Disease-related anemia is common and associated with an inferior quality of life and survival. Unfortunately, few therapies exist to improve hemoglobin in myelofibrosis patients. Momelotinib is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of hepcidin expression and increased availability of iron for erythropoiesis. In clinical testing, momelotinib has demonstrated a unique ability to improve hemoglobin and reduce transfusion burden in myelofibrosis patients with baseline anemia, while producing reductions in spleen size and symptom burden. This review explores the preclinical rationale, clinical trial data and future role of momelotinib in the evolving therapeutic landscape of myelofibrosis.
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| http://dx.doi.org/10.2217/fon-2022-0276 | DOI Listing |
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