This paper studies the dynamical characteristics of discrete analogue of impulsive recurrent neural networks with both discrete and finite distributed asynchronous time-varying delays. Firstly, the discrete impulsive system of the corresponding continuous-time model is reformed by impulsive maps and semi-discrete method. Secondly, by employing a famous delay impulsive differential inequality, several novel sufficient conditions are derived to ensure the uniqueness of equilibrium point and its global exponential stability in Lagrange sense for the discussed discrete-time impulsive system. Meanwhile, it is illustrated that the discrete-time analogue retains the uniqueness of equilibrium point of the corresponding continuous-time model, and some corollaries follow. Finally, one example is given to demonstrate the validity of our obtained results.
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http://dx.doi.org/10.1007/s11571-021-09739-1 | DOI Listing |
Int J Biol Macromol
January 2025
School of Physical Science and Technology, Ningbo University, Ningbo 315211, China; Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, United States. Electronic address:
Human calcitonin (hCT) is a peptide hormone that regulates calcium homeostasis, but its abnormal aggregation can disrupt physiological functions and increase the risk of medullary thyroid carcinoma. To elucidate the mechanisms underlying hCT aggregation, we investigated the self-assembly dynamics of hCT segments (hCT, hCT, and hCT) and the folding and dimerization of full-length hCT through microsecond atomistic discrete molecular dynamics (DMD) simulations. Our results revealed that hCT and hCT predominantly existed as isolated monomers with transient small-sized oligomers, indicating weak aggregation tendencies.
View Article and Find Full Text PDFJ Biomol Struct Dyn
December 2024
Amity Institute of Biotechnology, Amity University, Kolkata, India.
The first FDA approved, MDR-TB inhibitory drug bedaquiline (BDQ), entraps the c-ring of the proton-translocating F region of enzyme ATP synthase of , thus obstructing successive ATP production. Present-day BDQ-resistance has been associated with cardiotoxicity and mutation(s) in the atpE gene encoding the c subunit of ATP synthase (ATPc) generating five distinct ATPc mutants: Ala63→Pro, Ile66→Met, Asp28→Gly, Asp28→Val and Glu61→Asp. We created three discrete libraries, first by repurposing bedaquiline via scaffold hopping approach, second one having natural plant compounds and the third being experimentally derived analogues of BDQ to identify one drug candidate that can inhibit ATPc activity more efficiently with less toxic properties.
View Article and Find Full Text PDFACS Med Chem Lett
December 2024
Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, United States.
Meayamycins are synthetic analogs of the natural product FR901464 and exhibit potent anticancer activity against human cancers. They bind SF3B1 and PHF5A, components of the human spliceosome, and they alter pre-mRNA splicing. Detailed analysis of the active site led us to investigate a narrow pocket within the binding site that surrounds the α,β-unsaturated amide portion of meayamycin.
View Article and Find Full Text PDFCogn Process
December 2024
Departments of Computer Science and Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA.
Operant keypress tasks in a reinforcement-reward framework where behavior is shaped by its consequence, show lawful relationships in human preference behavior (i.e., approach/avoidance) and have been analogized to "wanting".
View Article and Find Full Text PDFIntern Med
December 2024
Department of Cardiovascular Medicine, St. Luke's International Hospital, Japan.
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