approaches to develop herbal acaricides against Anti-Tick activities of selected medicinal plants.

In tropical and sub-tropical areas of the world the most damaging pest of the livestock sector are cattle tick, The current study was aimed to generate phytochemical derived acaricides to control populations, to maintain livestock herd production, minimize economic losses and to reduce uses of man-made chemicals acaricides. To achieve this goal, Adult immersion and larval package test were used to determine the feasibility of and against ticks. Further, an technique was employed to discover biologically active substances from both plants using docking method. and exhibited a reasonably high fatal effect at 40.0 mg/L on egg laying (index of egg laying = 0.19 and 0.19) respectively, thus inhibiting the oviposition (49.5 and 45.1, respectively) and the larval mortality (97% and 93%, respectively). Further, we also used Chem-Draw ultra-software (v. 12.0.2.1076. 2010) to illustrate different structures of38 known bioactive phytochemicals which are discovered in the PubChem database and verify the hypothesis that tick inhibition was linked to acetylcholinesterase (AChE). Barbamunine and rutin from showed remarkable interaction with RmAChE1 active site residues with docking scores of -9.11 to -8.71 while phytol and dehydrodigallic acid from showed comparable docking scores of -7.17 and -7.14 respectively against acetylcholinesterase protein. Based on obtained result, we believe that and could be potential candidates in the control and management of and should be studied further as a supplement or replacement for synthetic acaricides.