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Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA.
Published: June 2022
AI Article Synopsis
The lateral septal nucleus (LSN) is an important part of the brain that connects with many other areas and affects how they work together.
Researchers found that certain neurons in the LSN can release two different chemicals: GABA and acetylcholine (ACh), which help communicate with other neurons.
This discovery could help us understand how changes in these chemicals might influence brain activity and behavior over time.
Article Abstract
The lateral septal nucleus (LSN) is a highly interconnected region of the central brain whose activity regulates widespread circuitry. As such, the mechanisms that govern neuronal activity within the LSN have far-reaching implications on numerous brain-wide nuclei, circuits, and behaviors. We found that GABAergic neurons within the LSN express markers that mediate the release of acetylcholine (ACh). Moreover, we show that these vGAT neurons release both GABA and ACh onto local glutamatergic LSN neurons. Using both short-term and long-term neuronal labeling techniques we observed expression of the cholinergic neuron marker Choline Acetyltransferase (ChAT) in vGAT neurons. These findings provide evidence of cholinergic neurotransmission from vGAT neurons, and provide an impetus to examine dynamic co-neurotransmission changes as a potential mechanism that contributes to neuronal and circuit-wide plasticity within the LSN.
