AI Article Synopsis
- Retinitis pigmentosa (RP) is a hereditary retinal disease that leads to gradual vision loss due to specific genetic mutations, influenced by various risk factors.
- Factors that may affect RP progression include genetic inheritance, age, gender, lifestyle habits (like smoking), and structural changes in the eye, as well as inflammation markers and oxidative stress.
- The review aims to consolidate existing research on these risk factors to create reliable predictive models for tracking the progression of RP.
Article Abstract
Retinitis pigmentosa (RP) is a commonly inherited disease of the retina, which is characterized by progressive loss of visual function due to specific genetic mutations. There are many risk factors that may have effect on the progression of RP, such as inheritance patterns, genotype, gender, age, smoking, physical activity, and other demographic and environmental factors. Baseline visual field conditions, changes of ellipsoid zone, photoreceptor layer thickness, and choroidal structure are reported to be the phenotype risk factors for RP progression. Moreover, aqueous flare and high-sensitivity C-reactive protein are probable inflammation biomarkers for assessing the progression of RP. Increased oxidative stress is considered to be one of the potential factors for the existence of RP. The risk factors can be combined to form a corresponding prediction model to predict disease progression. This review is to summarize the current literature that studies the genetic, environmental, phenotypic, demographic, inflammatory and other risk factors of RP progression and discuss the most reliable risk factors that could provide predictive models.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091890 | PMC |
| http://dx.doi.org/10.18240/ijo.2022.05.21 | DOI Listing |
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