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Identification and validation of transcriptome-wide association study-derived genes as potential druggable targets for osteoarthritis.
Bone Joint Res
March 2025
Department of Orthopedics, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China.
Aims: Osteoarthritis (OA) is a widespread chronic degenerative joint disease with an increasing global impact. The pathogenesis of OA involves complex interactions between genetic and environmental factors. Despite this, the specific genetic mechanisms underlying OA remain only partially understood, hindering the development of targeted therapeutic strategies.
View Article and Find Full Text PDFAssessing Environmental Justice in Mexico: How Polluting Industries and Healthcare Disparities Impact Congenital Heart Defects.
Birth Defects Res
March 2025
Neurometabolic Translational Research Center for Experimental Neurotherapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Background: Congenital heart defects (CHDs) are the most prevalent birth defects globally and the second leading cause of death in Mexican children under five. This study examines how industrial activity and social vulnerabilities independently and jointly influence CHD incidence across 2446 Mexican municipalities from 2008 to 2019.
Methods: Using negative binomial regression models, we evaluated associations between polluting industries, healthcare access, and CHD incidence.
Interplay of replication timing, DNA repair, and translesion synthesis in UV mutagenesis in yeast.
Nucleus
December 2025
School of Molecular Biosciences, Biotechnology Life Sciences, Washington State University, Pullman, WA, USA.
Replication timing during S-phase impacts mutation rates in yeast and human cancers; however, the exact mechanism involved remains unclear. Here, we analyze the impact of replication timing on UV mutagenesis in . Our analysis indicates that UV mutations are enriched in early-replicating regions of the genome in wild-type cells, but in cells deficient in global genomic-nucleotide excision repair (GG-NER), mutations are enriched in late-replicating regions.
View Article and Find Full Text PDFEthical issues surrounding the implementation of long-acting injectable antiretroviral therapy in sub-Saharan Africa.
Int Health
March 2025
Department of Global Health and Development, London School of Hygiene and Tropical Medicine, P.O Box WC1E 7HT, London, UK.
Background: This article discusses the ethical issues surrounding the integration of long-acting injectable antiretroviral therapy (LA-ART) in the programmatic management of human immunodeficiency virus (HIV). As the medical landscape evolves, implementing LA-ART introduces many ethical issues that should be considered for the success of scale-up in diverse settings.
Methods: This article examines key issues such as bioethical concerns around the rollout of LA-ART, including regulatory requirements, a person's autonomy, informed consent, privacy and confidentiality; the societal implications of providing LA-ART, including the impact on stigma and discrimination; ethics around who receives LA-ART, financial accessibility, equitable access, inclusive decision-making and cultural sensitivity; and the ethics of providing an expensive intervention, including cost-effectiveness, supply chain sustainability and resource allocation.
Impact of geo-climatic factors on the prevalence and diversity of tick fauna in Achai cattle of the northern Hindukush Mountains, Khyber pakhtunkhwa, Pakistan.
Trans R Soc Trop Med Hyg
March 2025
Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Background: Ticks are blood-feeding ectoparasites that can transmit different diseases in livestock and humans. Globally, 994 tick species are recognized, belonging to three families, that is, Argasidae (220 species), Ixodidae (773 species) and Nuttalliellidae (one species). The current study investigated the impact of geo-climatic conditions on the prevalence and distribution of ticks in Achai cattle of the northern Hindukush Mountains of Khyber Pakhtunkhwa.
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