Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro.

Virol Sin

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. Electronic address:

Published: April 2022

• A comprehensive evaluation method for anti-SARS-CoV-2 drugs was established based on qPCR, TCID, and immunofluorescence. • A significant antiviral effect of rHuIFN-α1b was shown in Vero and Calu-3 ​cells. • rHuIFN-α1b has a good potential in the application of anti-COVID-19 therapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786678PMC
http://dx.doi.org/10.1016/j.virs.2022.01.031DOI Listing

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