Pulmonary artery sarcomas are exceptionally unusual. Their clinic, diagnosis and treatment play a very important role in the ultimate outcome and long-term survival. We present the case of a 70-year-old gentleman diagnosed with a leiomyosarcoma of the pulmonary artery with osteosarcoma differentiation that underwent surgical resection and subsequent chemotherapy, with good recovery at 9 months follow-up. Late diagnosis and incomplete surgical resection will worsen the short- and long-term prognosis of these patients.
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http://dx.doi.org/10.1016/j.carpath.2022.107436 | DOI Listing |
Macromol Biosci
January 2025
Department of Pediatrics, Afyonkarahisar Health Sciences University, Afyonkarahisar, 03030, Türkiye.
Chemotherapy is generally given by intravenous (IV) administration which provides higher bioavailability than other systemic routes. However, in the case of lung cancer, the pulmonary (INH) route is the other choice for inhalable formulations. In the study, biochemical and histological parameters of Cabazitaxel (CBZ) free (2 mg kg) and nanoparticle (NP) (2 mg kg CBZ equivalent) formulations are investigated after IV and INH administration in rats.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
January 2025
Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
We present an 18-year-old male with Fallot's tetralogy (ToF) repaired with a transannular and main pulmonary artery (PA) patch, who suffered an acute coronary artery compression after a Harmony-TPV deployment. Left main coronary artery compression was confirmed with angiography and IVUS. He underwent emergent surgery, with a bioprosthetic valve replacement.
View Article and Find Full Text PDFJACC Case Rep
January 2025
Department of Cardiology, Málaga Regional University Hospital, Málaga, Spain.
Pickering syndrome, characterized by recurrent episodes of flash pulmonary edema (FPE) and renal impairment, is associated with renal artery stenosis (RAS). This case highlights its manifestation and management in an older adult patient. An 86-year-old woman with hypertension, chronic kidney disease, and a single functioning kidney presented with recurrent FPE episodes.
View Article and Find Full Text PDFJACC Case Rep
January 2025
Mécénat Cardiac Surgery, Paris, France.
Anatomically corrected malposition (ACM) of the great arteries is an exceedingly rare congenital heart disease. This conotruncal anomaly manifests with an L-malposition of the aorta (situs solitus, D loop, aorta to the left of the pulmonary artery) with normal ventriculoarterial concordance. A 14-month-old boy presented with an ACM associated with a ventricular septal defect that was successfully repaired.
View Article and Find Full Text PDFJACC Case Rep
January 2025
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Implantable hemodynamic devices like the CardioMEMS HF System are commonly used to manage fluid status in patients with heart failure (HF) by measuring pulmonary pressures. Although CardioMEMS has been shown to reduce HF hospitalizations, rare complications (eg, device endothelialization) can occur and warrant clinical attention. A 67-year-old woman with HF with preserved ejection fraction and group 2 pulmonary hypertension experienced recurrent HF exacerbations.
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