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Characterization and variability of PROMIS-10 scores with physical therapy in knee osteoarthritis: A retrospective review.
PM R
January 2025
Department of Physiatry, Hospital for Special Surgery, New York, New York, USA.
Background: Knee osteoarthritis (OA) and its impairments affect patients' physical and mental health. Radiographically severe knee OA is believed to respond less to conservative treatments including physical therapy (PT) but has not been compared specifically with Patient-Reported Outcomes Measurement Information System (PROMIS)-10.
Objective: To correlate baseline PROMIS-10 physical and mental health scores in patients undergoing PT for knee OA, subgrouped by radiographic severity (Kellgren-Lawrence [KL] grade and number of knee compartments involved).
Impact of Fatigue on Work Productivity, Activity Impairment, and Healthcare Resource Utilization in Inflammatory Bowel Disease.
Crohns Colitis 360
January 2025
Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.
Objectives: Fatigue is commonly reported in patients with Crohn's disease (CD) and ulcerative colitis (UC), including patients with inactive disease. We explored the impact of fatigue on healthcare utilization (HCU) and work productivity and activity impairment (WPAI).
Methods: Data collected between 2017 and 2022 were analyzed from the CorEvitas IBD Registry.
Racial disparities in prosthesis use, satisfaction, and physical function in upper limb amputation and the impact of veteran status.
PM R
November 2024
Research Department, Providence VA Medical Center, Providence, Rhode Island, USA.
Background: Prior research found that Black veterans with upper limb amputation (ULA) reported greater disability and need for assistance compared to White veterans. The extent to which racial disparities in outcomes exist outside of the Department of Veterans Affairs has not been explored.
Objective: To examine racial disparities in physical function and prosthesis satisfaction among individuals with ULA and assess the potential moderating role of veteran status.
AAV gene therapy for Duchenne muscular dystrophy: the EMBARK phase 3 randomized trial.
Nat Med
January 2025
Sarepta Therapeutics, Inc., Cambridge, MA, USA.
Article Synopsis
- - Duchenne muscular dystrophy (DMD) is a serious genetic condition linked to the absence of a protein called dystrophin, leading to severe mobility and respiratory problems, and is evaluated in the phase 3 EMBARK trial using a gene therapy called delandistrogene moxeparvovec.
- - The trial involved boys aged 4 to 8 with DMD who received either the gene therapy or a placebo, but results showed no significant improvement in the primary measure of motor function (NSAA score) after 52 weeks.
- - Although the primary endpoint wasn't met, some secondary measures did show improvement in muscle function and expression of micro-dystrophin, with a notable number of adverse events recorded but
Enhancement of STroke REhabilitation with Levodopa (ESTREL): Rationale and design of a randomized placebo-controlled, double blind superiority trial.
Eur Stroke J
December 2024
Neurology and Neurorehabilitation, University Department of Geriatric Medicine FELIX PLATTER, University of Basel, Basel, Switzerland.
Rationale: Novel therapeutic approaches are needed in stroke recovery. Whether pharmacological therapies are beneficial for enhancing stroke recovery is unclear. Dopamine is a neurotransmitter involved in motor learning, reward, and brain plasticity.
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