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Experience of continuous kidney replacement therapy in a tertiary care unit of a lower-middle-income country.
Pediatr Nephrol
January 2025
Pediatric Nephrology Services, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India.
Background: Information on the clinical characteristics and outcomes of children undergoing continuous kidney replacement therapy (CKRT) from lower-middle-income countries (LMIC) is limited.
Methods: Records of consecutive children 1 month to 18 years of age who underwent CKRT from Jan 2016 to Jan 2024 in a tertiary care pediatric intensive care unit (PICU) were retrospectively reviewed and analyzed for clinical and machine-related characteristics, and outcomes.
Results: Over the 8-year period, 102 patients (61.
MC16 promotes mitochondrial biogenesis and ameliorates acute and diabetic nephropathy.
Br J Pharmacol
January 2025
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Background And Purpose: Kidney disease (KD) is a leading cause of mortality worldwide, affecting 〉10% of the global population. Two of the most common causes of KD are diabetes and acute kidney injury (AKI), both of which induce mitochondrial dysfunction resulting in renal proximal tubular damage/necrosis. Thus, pharmacological induction of mitochondrial biogenesis (MB) may provide a therapeutic strategy to block the onset/progression of KD.
View Article and Find Full Text PDFEmploying a Haemodynamic Score to Predict Acute Kidney Injury in Infants With Patent Ductus Arteriosus.
Acta Paediatr
January 2025
Department of Paediatrics, RCSI University of Medicine & Health Sciences, Dublin 2, Ireland.
Aim: This study hypothesised that infants with a haemodynamically significant patent ductus arteriosus (hsPDA) as defined by a validated score have a higher incidence of acute kidney injury (AKI).
Methods: A retrospective study was conducted including infants < 29 weeks' gestation, born at the Rotunda Hospital. The El-Khuffash patent ductus arteriosus (PDA) severity score was applied following an echocardiographic assessment.
A 31-Year-Old Pregnant Woman with Fever, Acute Kidney Injury, Hypervolemia, and Lymphadenopathy.
Ann Am Thorac Soc
February 2025
Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine.
Calcium Phosphate-Induced Injury in Kidney Tubular Cells-Supersaturated Solution vs Preformed Crystals.
J Biochem Mol Toxicol
February 2025
Calcium Signaling Laboratory, Veterans Affairs Medical Center, Research Service, Washington, District of Columbia, USA.
Crystalline nephropathy (CN) is characterized by deposition of microcrystals within the kidney tubular microstructure, specifically in the renal tubular cells. Nephropathic conditions have been observed in kidney stone patients as nephrocalcinosis, resulting from the deposition of calcium phosphate (CaP) microcrystals mainly within the renal tubule. CaP microcrystals trigger nephrotoxicity and cell death leading to acute and chronic kidney disease and in some cases end stage renal disease.
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