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AQP3 Influences Unexplained Recurrent Abortion by Regulating Trophoblast Cell Migration and Invasion via the METTL14/IGF2BP1/AQP3/PI3K/AKT Pathway.
J Cell Mol Med
February 2025
Department of Reproductive Health and Infertility, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.
Reduced trophoblast migration and invasion contribute to unexplained recurrent spontaneous abortion (URSA). Aquaporin 3 (AQP3) plays a crucial role in facilitating trophoblast migration and invasion during early pregnancy through fetal-maternal crosstalk. This study aimed to comprehensively investigate the mechanism involving AQP3 and its modulatory effects on human extravillous trophoblast (HTR-8/SVneo cells) migration and invasion.
View Article and Find Full Text PDFEarlier pregnancies in nulliparous women with current father and lower risks for preeclampsia and low-birth weight newborns.
J Reprod Immunol
January 2025
Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, Kuopio, Finland; Department of Obstetrics and Gynaecology, Kuopio University Hospital, PL 100, Kuopio 70029, Finland. Electronic address:
New paternity has been related to placenta-associated complications in pregnancy. We evaluated whether a lack of earlier pregnancies or deliveries with a current father are associated with the pregnancy, prenatal, and early neonatal outcomes after controlling for the most common maternal confounders in prospective birth cohort study. An online questionnaire was used to survey 4459 pregnant women from the Kuopio Birth Cohort in their third trimester.
View Article and Find Full Text PDFEvaluation of placental growth factor, Vitamin D, and systemic inflammatory index as predictive biomarkers for preeclampsia severity: a retrospective cohort study.
BMC Pregnancy Childbirth
January 2025
Department of Gynecology and Obstetrics, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Aim: Our study aimed to evaluate the predictive value of Placental growth factor (PlGF), Vitamin D, and systemic inflammatory index for assessing preeclampsia risk and severity.
Materials And Methods: This retrospective cohort study included 457 pregnant individuals who delivered at our hospital between March 2023 and October 2024. Participants were divided into three groups: control (n = 217), mild preeclampsia (n = 101), and severe preeclampsia (n = 67).
A Case of Vasa Previa Diagnosed at Term: Elective Caesarean Section with Good Feto-Maternal Outcomes.
Int Med Case Rep J
January 2025
Department of Obstetrics and Gynecology, Universitas Padjadjaran, Bandung, Indonesia.
Vasa previa is a condition where unprotected fetal vessels, neither by placenta nor umbilical cord, lie within the membranes over the internal cervical ostium and beneath the presenting part of the fetus. Due to this condition, the membranous vessels pose a higher risk of being compressed or ruptures and could lead to fetal demise, exsanguination, or even fetal death. In this case report, we reported a case of a 36-year-old woman, G3P2A0, at term gestation and oblique lie.
View Article and Find Full Text PDFReproductive outcomes in female mice offspring due to maternal metformin treatment.
Life Sci
January 2025
Studies of the Physiopathology of the ovary laboratory, Institute of Biology and Experimental Medicine (IBYME) - National Scientific and Technical Research Council (CONICET), Vuelta de Obligado 2490, C1428ADL Buenos Aires, Argentina. Electronic address:
Aims: Metformin has shown beneficial effects on reproduction in women. However, its use during pregnancy remains controversial, as metformin can cross the placenta. Most studies have focused on the metabolic impact on the offspring of treated mothers, with limited information regarding its reproductive effects.
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