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Double-Negative CD4 CD8 Absolute Count Plays a Mediating Role in the Causal Relationship Between Plasma Lipids and Parkinson's Disease: A Mendel Randomized Study.
Mol Neurobiol
January 2025
Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Xuhui District, No. 725 South Wan-Ping Road, Shanghai, 200032, China.
According to certain research, there might be a connection between Parkinson's disease and plasma lipidome. However, the causal effects between plasma lipidome and Parkinson's disease and whether immune cells act as a mediator remain unclear. According to some research, plasma lipids are an important risk factor for Parkinson's disease, however, whether there is a causative connection between the two is unclear.
View Article and Find Full Text PDFPlant Breeding and the Origins of Genetics.
Cold Spring Harb Perspect Biol
November 2024
Department of Philosophy, Classics, History of Art and Ideas, University of Oslo, Blidern, 0315 Oslo, Norway
This paper argues that the historiography of genetics ∼1900, the formation period of modern science, is too narrow. It lacks attention to plant breeding. Perhaps this omission also narrows the present understanding of fundamental ideas like the genotype/phenotype distinction and the gene concept? There is a mythical story still told in textbooks and at anniversaries: As modern genetics started with the rediscovery of Mendel's laws in 1900, a fateful controversy over continuous or discontinuous variation of heredity between biometricians and Mendelians.
View Article and Find Full Text PDFThe Significance of Mendelism for Evolutionary Theory: A Reassessment.
Cold Spring Harb Perspect Biol
November 2024
Department of Philosophy, University of Bristol, Bristol BS8 1TH, United Kingdom
It is well-known that the rediscovery of Mendelian genetics at the turn of twentieth century offered Darwin's theory a much-needed lifeline, by showing how Fleeming Jenkins' famous "blending" objection could be rebutted. However, Mendelism has another fortuitous consequence for evolutionary biology that is less widely appreciated. By bequeathing the notion of allelism to biology, Mendelism shows how two difficult conceptual issues for evolutionary theory can be resolved.
View Article and Find Full Text PDFTeaching School Genetics in the 2020s: Why "Naive" Mendelian Genetics Has to Go.
Cold Spring Harb Perspect Biol
November 2024
Section of Biology and IUFE, University of Geneva, 1211 Geneva 4, Switzerland
Whereas Mendelian genetics is an important research program in the life sciences, its school version is problematic. On the one hand, it contains stereotypical representations of Gregor Mendel's work that misrepresent his findings and the historical context. This deprives students from gaining an authentic picture of how science is done.
View Article and Find Full Text PDFImmunocyte phenotype and breast cancer risk: A Mendel randomization analysis.
PLoS One
October 2024
First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Background: Breast cancer remains a significant global health challenge. Understanding its etiological factors, particularly the role of immune system components, is crucial. This study leverages Mendelian randomization (MR) to investigate the causal relationship between various immune cell features and the risk of developing breast cancer.
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