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[Progress in the study of the surgical management of Crohn disease based on the mesenteric concept].
Zhonghua Wai Ke Za Zhi
January 2025
Department of General Surgery (Colorectal Surgery), the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Biomedical Innovation Center, the Sixth Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou510655, China.
In recent years, with the deepening of mesentery research, it is found that its blood vessels, nerves, lymphoid tissue, adipose tissue and other structures play an important role in the occurrence and development of Crohn disease, and the degree of lesion is related with the disease process, surgical difficulty, the occurrence of intraoperative complications and postoperative recurrence. The optimal surgical strategy of Crohn disease based on mesenteric involvement has received great attention. Multiple retrospective studies found that extended mesenteric resection and Kono-S anastomosis potentially could reduce the rate of postoperative recurrence.
View Article and Find Full Text PDFPerceptions and Responses to Diseases among Patients with Inflammatory Bowel Disease: Text Mining Analysis of Posts on a Japanese Patient Community Website.
Inflamm Intest Dis
October 2024
Inflammatory Bowel Disease Center, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
Introduction: Patients with inflammatory bowel disease (IBD) are increasingly using online platforms to communicate with other patients and healthcare professionals seeking disease-related information and support. Free-text posts on these platforms could provide insights into patients' everyday lives, which could help improve patient care. In this proof-of-concept (POC) study, we applied text mining to extract patient needs from free-text posts on a community forum in Japan, holistically visualized the patients' perceptions and their connections, and explored the patient characteristic-dependent trends in the use of words.
View Article and Find Full Text PDFAltered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study.
Lancet Microbe
November 2024
Division of Infection and Immunity, University College London, London, UK. Electronic address:
Article Synopsis
- The study investigates the relationship between IL-6 signaling, particularly through the SNP rs2228145, and the risk of developing tuberculosis (TB), considering that inhibitors of IL-6 signaling might increase TB progression risk.
- The researchers conducted a meta-analysis of various genome-wide association studies (GWAS) to analyze genetic data and extract effect estimates related to the C allele of rs2228145, which is associated with reduced IL-6 signaling.
- Preliminary findings include data from 17 GWAS, covering a substantial sample of individuals with tuberculosis and a large control population, aiming to understand how genetic factors might influence TB susceptibility.
AGA Living Clinical Practice Guideline on Pharmacological Management of Moderate-to-Severe Ulcerative Colitis.
Gastroenterology
December 2024
Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Background & Aims: This American Gastroenterological Association (AGA) living guideline is intended to support practitioners in the pharmacological management of moderate-to-severe ulcerative colitis (UC).
Methods: A multidisciplinary panel of content experts and guideline methodologists used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework to prioritize clinical questions, identify patient-centered outcomes, conduct an evidence synthesis, and develop recommendations on the pharmacological management of moderate-to-severe UC.
Results: The AGA guideline panel made 14 recommendations.
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