Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S1473-3099(22)00286-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent developments and future directions in point-of-care next-generation CRISPR-based rapid diagnosis.
Clin Exp Med
January 2025
Department of Zoology, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
The demand for sensitive, rapid, and affordable diagnostic techniques has surged, particularly following the COVID-19 pandemic, driving the development of CRISPR-based diagnostic tools that utilize Cas effector proteins (such as Cas9, Cas12, and Cas13) as viable alternatives to traditional nucleic acid-based detection methods. These CRISPR systems, often integrated with biosensing and amplification technologies, provide precise, rapid, and portable diagnostics, making on-site testing without the need for extensive infrastructure feasible, especially in underserved or rural areas. In contrast, traditional diagnostic methods, while still essential, are often limited by the need for costly equipment and skilled operators, restricting their accessibility.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
London School of Hygiene and Tropical Medicine, London, United Kingdom.
Background: Some infections may be associated with poor brain health, but evidence from low and middle-income countries (LMICs) is limited. Therefore, we aimed to investigate associations between nine infections and cognitive function, depression, and frailty in India.
Methods: We conducted a cross-sectional study using data from Wave 1 (2017-2019) of the Longitudinal Aging Study in India (LASI) survey of adults (≥45years) from 35 of India's 36 states and union territories.
A blended learning approach for capacity strengthening to improve the quality of integrated HIV, TB, and malaria services during antenatal and postnatal care in LMICs: a feasibility study.
BMC Med Educ
January 2025
Department of International Public Health, Emergency Obstetric and Quality of Care Unit, Liverpool School of Tropical Medicine, Pembrooke Place, L3, 5QA, Liverpool, UK.
Background: The blended learning (BL) approach to training health care professionals is increasingly adopted in many countries because of high costs and disruption to service delivery in the light of severe human resource shortage in low resource settings. The Covid-19 pandemic increased the urgency to identify alternatives to traditional face-to-face (f2f) education approach. A four-day f2f antenatal care (ANC) and postnatal care (PNC) continuous professional development course (CPD) was repackaged into a 3-part BL course; (1) self-directed learning (16 h) (2) facilitated virtual sessions (2.
View Article and Find Full Text PDFCorrigendum to "Structure-based development of N-Arylindole derivatives as Pks13 inhibitors against Mycobacterium tuberculosis" [Europ. J. Med. Chem. 283 (2025) 117148].
Eur J Med Chem
January 2025
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China. Electronic address:
Expression and purification of Mycobacterium tuberculosis F-dependent glucose-6-phosphate dehydrogenase enzyme using Escherichia coli.
Protein Expr Purif
January 2025
Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, 131 Princess St, Manchester, M1 7DN, United Kingdom. Electronic address:
Since their discovery in Mycobacterium tuberculosis (Mtb), F-dependent enzymes have been identified as both important drug targets and potential industrial biocatalysts, including for bioremediation of otherwise recalcitrant substrates. Mtb-FGD1, utilizes glucose 6-phosphate (G6P) as an electron donor for the reduction of F. Current expression systems for Mtb-FGD1 use Mycobacterium smegmatis as host, because of the tendency for it to form inclusion bodies in E.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!