Estimation of Cumulative Activity of Lu-Cetuximab from a Single Diagnostic Cu-Cetuximab Scan.

Cancer Biother Radiopharm

CHU de Bordeaux, Bordeaux, France.

Published: June 2022

This study aimed at investigating whether a single diagnostic Cu-cetuximab scan might predict therapeutic Lu-cetuximab cumulative activity in a preclinical study. The framework of the reversible Patlak-Blasberg analysis was used to derive two independent equations of Lu-cetuximab cumulative activity that involve the tumor-to-blood standard uptake value ratio (i.e., the SUR) assessed at peak-time of either decay-uncorrected or decay-corrected activity concentration of trapped Cu-cetuximab, respectively. Applied to published data in TE-8 tumor-bearing mice, the two peak times and corresponding SUR values were assessed. Two estimates of Lu-cetuximab cumulative activity were then computed for comparison with two previously published values obtained from different methods. The two estimates of Lu-cetuximab cumulative activity, computed at 14 and 59 h postinjection, were consistent with the previously published values: 4.7 × 10 and 5.5 × 10 versus 4.1 × 10 and 5.3 × 10 disintegrations/g. Two independent equations are proposed for estimating Lu-cetuximab cumulative activity from an initial diagnostic Cu-cetuximab scan, when acquired at two relevant injection acquisition times, respectively. Applied to published tumor-bearing mouse data, the Cu-cetuximab SUR assessed at either 14 or 59 h postinjection turns out to be key metrics.

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Source
http://dx.doi.org/10.1089/cbr.2022.0006DOI Listing

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