Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome.

Clin Endocrinol (Oxf)

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Published: August 2022

AI Article Synopsis

  • Polycystic ovary syndrome (PCOS) affects 8%-13% of women of reproductive age and is the most common endocrine disorder for this group.
  • The causes of PCOS are complicated, involving genetics, early hormone exposure, and body weight issues that disrupt normal ovarian function.
  • The symptoms of PCOS can vary greatly and can start in early adolescence, leading to various reproductive, metabolic, and psychological issues in adult life; the review will also address difficulties in diagnosing and understanding the progression of the condition.

Article Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting 8%-13% of reproductive-aged women. The aetiology of the syndrome is complex, with genetic susceptibility, androgen exposure in early life and adiposity related dysfunction leading to perturbance in hypothalamic-ovarian function. PCOS clinical features are heterogeneous, with manifestations arising even in early adolescence, developing into multisystem reproductive, metabolic and psychological manifestations in adulthood. In this review, we will discuss challenges in the diagnosis of PCOS and understanding of the natural history of PCOS.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541175PMC
http://dx.doi.org/10.1111/cen.14757DOI Listing

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