Meroterpenoid Dimers from Mushrooms and Their Biological Activities Against Triple Negative Breast Cancer Cells.

(±)-Dimercochlearlactones A-J (-), ten pairs of novel meroterpenoid dimers and one known spirocochlealactone A (), were isolated from mushrooms. The structural elucidation of new compounds, including their absolute configurations, depends on spectroscopic analysis and electronic circular dichroism (ECD) calculations. Biological studies showed that (+)- and (-)-, (-)-, and (+)- and (-)- are cytotoxic toward human triple negative breast cancer (TNBC) cells (MDA-MB-231) with IC values of 28.18, 25.65, 11.16, 8.18, and 13.02 μM, respectively. Wound healing assay revealed that five pairs of meroterpenoids (±)--(±)- and (±)- could significantly inhibit cell mobility at 20 μM in MDA-MB-231 cells. The results provide a new insight into the biological role of meroterpenoids in TNBC.