In the study, an investigation was made into the hydrolytic degradation behavior of the microporous polylactide (PLA) in the initial stage in three biological buffer solutions with various pH-simulating body fluids in comparison with pure PLA. Studies also include the analysis of selected mechanical properties and physical structures. A microporous PLA was obtained by melt extrusion using a chemical blowing agent. The rate of Mw decrease induced by hydrolysis over 35 days of microporous PLA was roughly comparable to the pure material. The rate of depolymerization was slightly accelerated at an acid pH due to acid-catalyzed hydrolysis at the end of the observed period. The mechanical analysis showed the influence of various pH on the obtained results.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101509 | PMC |
| http://dx.doi.org/10.3390/ma15093133 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing compatibility of polylactic acid and lignin through acetylation for improving controlled release of pesticide.
Pest Manag Sci
January 2025
College of Chemistry and Chemical Engineering, Guangxi University, Nanning, China.
Background: Improving the compatibility between polylactic acid (PLA) and lignin is crucial for developing innovative PLA-based controlled release systems for pesticides. This study addresses the challenge of enhancing the compatibility of alkali lignin (AL) with PLA by acetylated lignin (ACL). The main aim is to synthesize and evaluate pesticide-loaded microspheres for controlled release performance using fluazinam (FZ) as the model pesticide.
View Article and Find Full Text PDFMicroporous polylactic acid/chitin nanocrystals composite scaffolds using in-situ foaming 3D printing for bone tissue engineering.
Int J Biol Macromol
November 2024
CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; Fujian Universities and Colleges Engineering Research Center of Modern Facility Agriculture, Fujian Polytechnic Normal University, Fuzhou 350300, China. Electronic address:
Bone injury represents an urgent clinical problem, and implantable bioscaffolds offer suitable means for replacing and regenerating damaged tissues. This paper proposes an in-situ foaming printing method employing material extrusion additive manufacturing technology and physical foaming to prepared poly(lactic acid)/chitin nanocrystals (CHNCs) microporous composite scaffolds, featuring pore sizes ranging from 9 ± 5 μm. This method offers a novel strategy for the preparation of poly(lactic acid)-based scaffolds with good biocompatibility.
View Article and Find Full Text PDFStudy of Manipulative In Situ Pore-Formation upon Polymeric Coating on Cylindrical Substrate for Sustained Drug Delivery.
Macromol Biosci
December 2024
Department of Materials Science and Engineering, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, China.
Herein, the micro-porous polylactic acid coating applied on the surface of the cylindrical substrate is fabricated by a novel in situ pore-formation strategy based on the combinational effect of breath figure (BF) and vapor-induced phase separation (VIPS) processes. Under the condition of high environmental humidity, solvent pair of chloroform and dimethylformamide is employed for post-treatment onto pre-formed PLA coating to induce the pore-formation following the mechanism of BF and VIPS, respectively. A composite porous structure with both cellular-like and bi-continuous network morphologies is obtained.
View Article and Find Full Text PDF[Construction of a novel tissue engineered meniscus scaffold based on low temperature deposition three-dimenisonal printing technology].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
June 2024
Institute of Orthopedics, the First Medical Center of the Chinese PLA General Hospital, Beijing Key Laboratory of Orthopaedic Regenerative Medicine, Key Laboratory of Orthopaedic War Trauma, Beijing, 100853, P. R. China.
Objective: To investigate the construction of a novel tissue engineered meniscus scaffold based on low temperature deposition three-dimenisonal (3D) printing technology and evaluate its biocompatibility.
Methods: The fresh pig meniscus was decellularized by improved physicochemical method to obtain decellularized meniscus matrix homogenate. Gross observation, HE staining, and DAPI staining were used to observe the decellularization effect.
Influence of biodegradable plastics on the generation of disinfection byproducts in the chlorination process.
Chemosphere
August 2024
College of Environmental Science and Engineering/Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Nankai University, Tong Yan Road 38, Tianjin, 300350, China. Electronic address:
Biodegradable plastics (BPs) have seen a continuous increase in annual production and application due to their environmentally sustainable characteristics. However, research on the formation of disinfection byproducts (DBPs) from biodegradable microplastics (BMPs) during chlorination is limited, and the effects of aqueous solution chemistry on this process have yet to be explored. Therefore, two biodegradable microplastics, polylactic acid (PLA) and polybutylene adipate terephthalate (PBAT), were investigated in this study to examine the changes in their physicochemical properties before and after chlorination, and the formation of DBPs under different environmental conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!