Measurement of irreversibility and entropy production via the tubular ensemble.

The appealing theoretical measure of irreversibility in a stochastic process, as the ratio of the probabilities of a trajectory and its time reversal, cannot be accessed directly in experiments since the probability of a single trajectory is zero. We regularize this definition by considering, instead, the limiting ratio of probabilities for trajectories to remain in the tubular neighborhood of a smooth path and its time reversal. The resulting pathwise medium entropy production agrees with the formal expression from stochastic thermodynamics and can be obtained from measurable tube probabilities. Estimating the latter from numerically sampled trajectories for Langevin dynamics yields excellent agreement with theory. By combining our measurement of pathwise entropy production with a Markov chain Monte Carlo algorithm, we infer the entropy-production distribution for a transition path ensemble directly from short recorded trajectories. Our work enables the measurement of irreversibility along individual paths and path ensembles in a model-free manner.