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Multimodal Brain MRI of Deep Gray Matter Changes Associated With Inflammatory Bowel Disease. | LitMetric

AI Article Synopsis

  • Behavioral symptoms such as mood disorders significantly reduce the quality of life for patients with inflammatory bowel disease (IBD), even when they are in clinical remission.
  • A study involving MRI scans showed that IBD patients had increased brain activity, functional connectivity, and brain region volumes (especially in the amygdala and hypothalamus) linked to emotional and cognitive processing, compared to healthy individuals.
  • The findings suggest that the structural and functional brain changes in IBD patients could be potential targets for therapeutic strategies to address their emotional and cognitive challenges.

Article Abstract

Background: Behavioral symptoms, including mood disorders, substantially impact the quality of life of patients with inflammatory bowel disease (IBD), even when clinical remission is achieved. Here, we used multimodal magnetic resonance imaging (MRI) to determine if IBD is associated with changes in the structure and function of deep gray matter brain regions that regulate and integrate emotional, cognitive, and stress responses.

Methods: Thirty-five patients with ulcerative colitis (UC) or Crohn's disease (CD) and 32 healthy controls underwent 3 Tesla MRIs to assess volume, neural activity, functional connection strength (connectivity), inflammation, and neurodegeneration of key deep gray matter brain regions (thalamus, caudate, pallidum, putamen, amygdala, hippocampus, and hypothalamus) involved in emotional, cognitive and stress processing. Associations with sex, presence of pain, disease activity, and C-reactive protein (CRP) concentration were examined.

Results: Significantly increased activity and functional connectivity were observed in cognitive and emotional processing brain regions, including parts of the limbic system, basal ganglia, and hypothalamus of IBD patients compared with healthy controls. Inflammatory bowel disease patients exhibited significantly increased volumes of the amygdala and hypothalamus, as well as evidence of neurodegeneration in the putamen and pallidum. Hippocampal neural activity was increased in IBD patients with active disease. The volume of the thalamus was positively correlated with CRP concentration and was increased in females experiencing pain.

Conclusions: Patients with IBD exhibit functional and structural changes in the limbic and striatal systems. These changes may be targets for assessing or predicting the response to therapeutic interventions aimed at improving comorbid emotional and cognitive symptoms.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977255PMC
http://dx.doi.org/10.1093/ibd/izac089DOI Listing

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